期刊
TETRAHEDRON LETTERS
卷 56, 期 47, 页码 6556-6559出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.10.005
关键词
2-Alkylpyridines; Chiral auxiliary; Trifluoromethyl; Nucleophilic addition; Asymmetric
资金
- Innovation Program of Shanghai Municipal Education Commission [13ZZ047]
- Fundamental Research Funds for the Central Universities [2232015D3-13]
A novel strategy was developed to synthesize fluorinated 2-(pyridin-2-yl) alkylamines via condensation of 2-alkylpyridines and chiral fluoromethyl N-tert-butyl sulfinyl imines with good diastereo-control and good chemical yields. The chiral N-tert-butyl sulfinyl auxiliary can be easily removed under mild acidic condition at room temperature. The application of this strategy was demonstrated in the synthesis of a fluorine-containing pesticide candidate. (C) 2015 Elsevier Ltd. All rights reserved.
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