期刊
OPHTHALMIC GENETICS
卷 31, 期 4, 页码 235-239出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/13816810.2010.518578
关键词
Choroideremia carrier; Lyon hypothesis; Microperimetry; Optical coherence tomography (OCT)
资金
- Foundation Fighting Blindness, Owing Mills, Maryland
- Grant Healthcare Foundation, Chicago, Illinois
Purpose: To evaluate structural retinal changes and macular function by a combined spectral domain optical coherence tomography/scanning laser ophthalmoscope (OCT/SLO) microperimetry device in choroideremia carriers. Methods and Materials: Ten choroideremia carriers were included in the study. All subjects had a complete ophthalmic examination in addition to Goldmann kinetic visual fields, OCT and microperimetry testing on a commercially available Spectral Domain (SD) OCT/SLO combination system. Results: Microperimetry results demonstrated focal areas of threshold abnormalities in 50% of the subjects. OCT findings show subtle retinal pigment epithelium (RPE) irregularities with attenuation more pronounced outside the macular region. Conclusions: Long term follow up with microperimetric testing could be useful in monitoring any progressive loss of retinal function in choroideremia carriers.
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