期刊
TETRAHEDRON LETTERS
卷 56, 期 28, 页码 4215-4219出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.05.058
关键词
Depsipeptide; Sponge peptide; Stelletta; Anti-HIV
资金
- Frederick National Laboratory for Cancer Research, National Institutes of Health [HHSN261200800001E]
- Intramural Research Program of NIH, National Laboratory for Cancer Research, Center for Cancer Research
- Korea Institute of Ocean Science Technology [PE98816]
Two new HIV-inhibitory depsipeptides, stellettapeptins A (1) and B (2), were isolated from an extract of the marine sponge Stelletta sp., collected from northwestern Australia. Structures of these cyclic nonribosomal peptides were elucidated on the basis of extensive NMR data analysis, and chemical degradation and derivatization studies. Stellettapeptins contain numerous nonproteinogenic amino acid residues and they are the first peptides reported to contain a 3-hydroxy-6,8-dimethylnon-4-(Z)-enoic acid moiety. Compounds 1 and 2 potently inhibit infection of human T-lymphoblastoid cells by HIV-I-RF with EC50 values of 23 and 27 nM, respectively. Published by Elsevier Ltd.
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