Convenient copper-mediated Chan-Lam coupling of 2-aminopyridine: facile synthesis of N-arylpyridin-2-amines

A new and practical process for the synthesis of N-arylpyridin-2-amine derivatives has been developed. Under the assistance of copper, the desired products were produced from commercially available 2-aminopyridine and aryl boronic acids in moderate to good yields with good functional group tolerance. (C) 2015 Elsevier Ltd. All rights reserved.