期刊
TETRAHEDRON LETTERS
卷 56, 期 29, 页码 4383-4387出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.05.093
关键词
Natural products; Total synthesis; 2-Arylbenzo[b]furan; Moracin; Artocarpus
资金
- National Natural Science Foundation of China [21222211, 21372001, 91313303]
- Program for New Century Excellent Talents in University [NCET-12-0853]
- China Postdoctoral Science Foundation [2014M551361]
- 'Shu Guang' project - Shanghai Municipal Education Commission
- 'Shu Guang' project - Shanghai Education Development Foundation [14SG28]
- Fundamental Research Funds for the Central Universities
In this study, 2-arylbenzo[b]furan-containing derivatives moracin C (1) and moracin M (4), the natural products from Artocarpus, have been synthesized in highest overall yield to date (1, 7 steps with an overall yield of 41.9%; 4, 6 steps with an overall yield of 56.3%), and we also report the first total synthesis of artoindonesianin B-1 (2), another member of this family, in the same route (8 steps with an overall yield of 11.3%). This discovery provides a concise route for preparing enough amounts of 1, 2, and 4 as well as 2-arylbenzo[b]furan-containing natural product-like analogs (71-74) to explore the biological potential. (C) 2015 Elsevier Ltd. All rights reserved.
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