期刊
TETRAHEDRON LETTERS
卷 56, 期 30, 页码 4480-4482出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.05.100
关键词
Fluorobutenyl-tosylate; N-Fluorobutenyl-nortropane; Fluorine-18; Positron emission tomography
资金
- NIH/NIMH [1-R21-MH-66622-01, 2U19 MH069056]
The trans-fluoro-2-butenyl group has been previously utilized as an N-substituent on several nortropanes for imaging the dopamine transporter with positron emission tomography. We report here a simplified and shorter synthesis of trans-1-tosyloxy-4-substituted-2-butenes using Ag(I) salts. This methodology was also applied to the synthesis of the cis-isomers. Furthermore, these procedures allow for the recovery of the majority of the Ag(I) ions. (C) 2015 Elsevier Ltd. All rights reserved.
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