期刊
ONKOLOGIE
卷 35, 期 11, 页码 651-656出版社
KARGER
DOI: 10.1159/000343637
关键词
Esophagus; Squamous cell carcinoma; Matrix metalloproteinase-1; Vascular endothelial growth factor-C; Prognosis
类别
资金
- National Science Research Program of Education Bureau of Anhui Province [KJ2011A203]
- Natural Science Foundation of Anhui Province [070413089]
- Education Department of Anhui Province Colleges [2009SQRZ130]
- Outstanding Talent Fund of Institutes and Universities of Anhui Province [2011SQRL081]
Background: This study addresses the association of matrix metalloproteinase-1 (MMP-1) and vascular endothelial growth factor-C (VEGF-C) expression in esophageal squamous cell carcinoma (SCC) with clinicopathologic characteristics in the patients. Material and Methods: We profiled the expression of MMP-1 and VEGF-C by cDNA microarray in 4 cases and by reverse transcription-polymerase chain reaction (RT-PCR) in 14 cases of esophageal SCC. Another 90 cases were reviewed by immunohistochemical examination of paraffin-embedded sections. Results: Expression of MMP-1 and VEGF-C mRNA in normal esophageal tissue and tumor tissue was compared. Data were fully consistent with the results of RT-PCR. Immunohistochemistry showed that compared to the normal mucosa MMP-1 and VEGF-C protein expression was upregulated in both esophageal atypical hyperplasia (n = 16) and esophageal SCC. Depth of tumor invasion, lymph node metastasis, and clinical stage were directly associated with prognosis in all cases. Furthermore, median overall survival and disease-free survival were significantly shorter in patients with a higher expression of MMP-1 and VEGF-C than in patients with lower expression levels. Conclusion: We demonstrated that the expression of both MMP-1 and VEGF-C mRNA and protein was upregulated in esophageal SCC tissues. Protein expression was associated with progressive tumor stage and poor prognosis in patients with esophageal SCC.
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