期刊
ONCOLOGY RESEARCH
卷 18, 期 8, 页码 359-364出版社
COGNIZANT COMMUNICATION CORP
DOI: 10.3727/096504010X12644422320582
关键词
Cyclin Y (CCNY); Glioma; RNAi
类别
资金
- National Education Committee of China [0220021]
Cyclin Y (CCNY) is a novel cyclin and almost nothing is known about its expression level and role in human cancers. In the present study, we found that lentivirus-mediated RNA interference (MAD of CCNY significantly downregulated its expression level. More importantly, knockdown of CCNY inhibited cell proliferation, colony formation, and cell cycle progression in glioma cells. These data suggest that CCNY might play an important role in glioma tumorigenisis.
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