期刊
ONCOLOGY REPORTS
卷 32, 期 4, 页码 1341-1346出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2014.3355
关键词
apoptosis; HT-29 cells; phloroglucinol
类别
资金
- Fishery Commercialization Technology Development Program through iPET (Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries) - Ministry of Oceans and Fisheries (MOF) [111090-03-3-HD110]
Phloroglucinol is a polyphenolic compound that is used to treat and prevent several human diseases, as it exerts beneficial biological activities, including anti-oxidant, anti-inflammatory and anticancer properties. The aim of the present study was to investigate the effects of phloroglucinol on apoptotic signaling pathways in HT-29 colon cancer cells. The results indicated that phloroglucinol suppressed cell viability and induced apoptosis in HT-29 cells in a concentration-dependent manner. Phloroglucinol treatment of HT-29 cells resulted in characteristic apoptosis-related changes: altered Bcl-2 family proteins, cytochrome c release, and activation of caspase-3 and caspase-8. This study also showed that proteins involved in apoptosis were stimulated by treatment with phloroglucinol. These findings demonstrated that phloroglucinol exerts anticancer activity in HT-29 colon cancer cells through induction of apoptosis.
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