期刊
ONCOLOGY REPORTS
卷 32, 期 6, 页码 2485-2492出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2014.3518
关键词
pancreatic cancer; epithelial-mesenchymal transition; metastasis-associated lung adenocarcinoma transcript-1; invasion; long noncoding RNA
类别
资金
- National Natural Science Foundation of China [81101846, 81171887, 91229117, 31101016]
- Program of Shanghai Subject Chief Scientist [12XD1404200]
- Shanghai International Science and Technology Cooperation Project [12410709000]
- Shanghai Science and Technology Committee [11DZ1922002]
Pancreatic cancer is one of the most aggressive solid malignancies with a dismal survival rate. Recent studies have shown that high expression levels of long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) correlate with several solid tumors. However, the underlying molecular mechanisms and its clinical significance in pancreatic cancer remain to be elucidated. In the present study, our results showed that MALAT-1 expression levels were upregulated in pancreatic cancer tissues compared with adjacent noncancerous controls. Consistently, higher expression level of MALAT-1 was found in all seven pancreatic cancer cell lines relative to the human pancreatic ductal epithelial cell. Further function analysis revealed that downregulation of MALAT-1 could inhibit tumor cell proliferation and decrease cell migration and invasion in vitro. The underlying mechanisms are possibly involved in inducing G(2)/M cell cycle arrest, promoting cell apoptosis, suppressing epithelial-mesenchymal transition and reducing cancer stem-like properties. In conclusion, this study indicated that MALAT-1 may serve as an oncogenic lncRNA that is involved in malignancy phenotypes of pancreatic cancer. Therefore, it may be used as a potential therapeutic target.
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