期刊
ONCOLOGY REPORTS
卷 31, 期 6, 页码 2820-2826出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2014.3162
关键词
esophageal squamous cell carcinoma; dipeptidyl peptidase IV; CD26; fibroblast activation protein-alpha; seprase; metalloproteinases
类别
To better understand the role of membrane-associated proteolytic systems in the development of esophageal cancer, we studied the expression of two serine proteases, fibroblast activation protein-alpha (FAP-alpha) and dipeptidyl peptidase IV (DPPIV) and three metalloproteinases, matrix metalloproteinase (MMP)-2, MMP-9 and MT1-MMP in 24 primary esophageal squamous cell carcinoma (ESCC) tissues and paired non-cancer tissues. Using reverse-transcription PCR, western blotting and zymography, we showed that both serine proteases and all three metalloproteinases were highly altered in ESCC. A positive correlation between the expression of FAP-alpha and DPPIV and the activity of both gelatinases was found. This may indicate that these proteolytic systems are tightly linked to each other and collectively are involved in the process of ECM degradation that facilitates cancer cell invasion and metastasis.
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