期刊
ONCOLOGY REPORTS
卷 32, 期 5, 页码 2127-2133出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2014.3439
关键词
ovarian carcinoma; microRNA; miR-497; angiogenesis; VEGFA; AKT; ERK
类别
资金
- National Natural Science Foundation of China [81171986]
- Basic and Advanced Technology Research Foundation of Henan Province [112300410153]
MicroRNAs (miRNAs) have been shown to play an important role in diverse biological processes and cancer progression. The objective of the present study was to investigate the role of miR-497 in ovarian cancer angiogenesis. We found that miR-497 expression was downregulated in human ovarian cancer tissues, and the low miR-497 expression was significantly associated with increased angiogenesis. Functionally, exogenous expression of miR-497 suppressed the ability of ovarian cancer cells to promote capillary tube formation of endothelial cells. We further disclosed that miR-497 exerted its function of anti-angiogenesis by suppressing VEGFA expression in ovarian cancer cells and, in turn, impairing the VEGFR2-mediated PI3K/AKT and MAPK/ERK pathways. Our findings suggest that downregulation of miR-497 may contribute to angiogenesis in ovarian cancer. miR-497 may be a promising candidate target for prevention and treatment of ovarian cancer.
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