期刊
ONCOLOGY REPORTS
卷 33, 期 1, 页码 133-140出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2014.3580
关键词
USP22; transforming growth factor-1; cell cycle; tumor growth; ovarian carcinoma
类别
资金
- National Natural Science Foundation of China [81202070]
- Basic and Advanced Technology Research Foundation from the Science and Technology Department of Henan Province [112102310105]
Ubiquitin specific protease 22 (USP22) is an oncogene that is upregulated in many cancer types, and aberrant expression of USP22 correlates with clinical outcome. However, its potential functional impact in epithelial ovarian cancer (EOC) has not been determined. Here, we report that USP22 was upregulated in EOC specimens and EOC cell lines with important functional consequences. A high level of USP22 in EOC tissues was associated with advanced clinical FIGO stage, lymph node metastasis and worse prognosis. Patients with higher USP22 expression had shorter relapse-free and overall survival. Depletion of USP22 suppressed cell proliferation in vitro and tumor growth in vivo. We found that inhibition of USP22 suppressed cell proliferation by inducing G1 phase cell cycle arrest through synergy with oncogenic transforming growth factor-1 (TGFB1). Our results indicate that USP22 functions as an oncogene in EOC, and thus USP22 may serve as a potential therapeutic target for individualized EOC treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据