期刊
ONCOLOGY REPORTS
卷 30, 期 5, 页码 2020-2026出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2013.2690
关键词
Hedgehog; cell signal; hepatocellular carcinoma; targeting therapy
类别
资金
- National Natural Scientific Foundation of China [81272645, 81072052]
- Research Fund for the Doctoral Program of High Education of China from the Ministry of Education [20120201120090]
- Fundamental Research Funds for the Basic Research Operating Expenses Program of Central College
- Xi'an Jiaotong University
The Hedgehog (Hh) pathway is an evolutionarily conserved signaling mechanism that controls many aspects of cell differentiation and the development of tissues and organs during embryogenesis. Early investigations have focused on the effects of Hh activity on the development of organs including skin, gut, the nervous system and bone. However, in addition to normal developmental processes, these investigations also found that Hh signaling is involved in aberrant proliferation and malignant transformation. Consequently, the role of Hh in cancer pathology, and its modulation by environmental factors is the subject of many investigations. Numerous environmental toxins, alcohol, and hepatitis viruses can cause hepatocellular carcinoma (HCC), which is the most common form of liver cancer. Significant hyperactivation of Hh signaling has been observed in liver injury and cirrhosis which often leads to the development of HCC lesions. Moreover, Hh activity plays an important role in the progression of HCC. Here, we review findings relevant to our understanding of the role of Hh signaling in HCC pathogenesis.
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