期刊
ONCOLOGY REPORTS
卷 28, 期 5, 页码 1778-1784出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2012.1964
关键词
tumor growth; breast neoplasm; lymphatic metastasis; RNA interference; targeted therapy
类别
资金
- National Natural Science Foundation of China [30872521]
In this study, we investigated the effects of lentivirus (LV)-mediated short hairpin RNA (shRNA) targeting IGF-1R on the growth and lymphangiogenesis of breast cancer. The LV vector effectively delivered the IGF-1R shRNA to MDA-MB-231 cells, leading to significant reduction of IGF-1R mRNA and protein expression. Infection of MDA-MB-231 cells with LV-IGF-1R shRNA reduced cell growth and migration. Transplantation of MDA-MB-231 cells with suppressed IGF-1R expression in SCID mice reduced tumor growth and lymphangiogenesis. These data collectively suggest that LV-mediated shRNA is an effective way to suppress IGF-1R expression and to inhibit growth and lymphangiogenesis of breast cancer. Specific inhibition of IGF-1R expression with shRNA represents a promising approach for the treatment of breast cancer.
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