期刊
TETRAHEDRON
卷 71, 期 18, 页码 2698-2707出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2015.03.037
关键词
C-Acylation; beta-Triketone; One-pot synthesis; Acylation agent induced racemization
The mechanistic aspects of the one-pot C-acylation of cyclic 1,3-diones are discussed. Using various substituted carboxylic acids, coupling agents and basic catalysts we aim to describe the process of direct transfer of an acyl group to the activated C-2 carbon of dimedone and 1,3-cyclohexanedione. The course of acylation was studied by high-perforrnance liquid chromatography as well as on-line infrared spectroscopy. The results indicate that the direct acylation follows a nucleophilic acyl substitution mechanism rather than a nucleophilic attack on a ketene intermediate formed in situ from the activated carboxylic acid. (C) 2015 Elsevier Ltd. All rights reserved.
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