Truncateols A-N, new isoprenylated cyclohexanols from the sponge-associated fungus Truncatella angustata with anti-H1N1 virus activities

Fourteen new isoprenylated cyclohexanols namely truncateols A-N (1-14) were isolated from the solid culture of the sponge-associated fungus Truncatella angustata. Their structures were determined on the basis of extensive spectroscopic analyses, including the modified Mosher's method and ECD, as well as X-ray diffraction for the assignment of absolute configurations. The structures of truncateols are characterized by the presence of unique alkynyl or allenyl groups. Truncateol M (13) exerted potent inhibitory effect against influenza-A viral infection by targeting virion assembly/release step. (C) 2015 Elsevier Ltd. All rights reserved.