期刊
ONCOLOGY REPORTS
卷 23, 期 6, 页码 1493-1500出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or_00000788
关键词
lung cancer; susceptible genes; gene polymorphism; smoking; meta-analysis
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan (IO) [13557034]
- Grants-in-Aid for Scientific Research [13557034] Funding Source: KAKEN
The polymorphism of CYP1A1*2A or CYP1A1*2B, and the linkage of CYP1A1*2A, CYP1A1*2B, GSTM1 and GSTT1 polymorphisms have been established as susceptible genes or gene-gene interactions of tobacco-related lung cancer. New candidate genes susceptible for lung cancer such as NQO1 (NAD(P)H:quinine oxidoreductase), NAT2 (N-acetyltransferase 2), and several others have been reported. In the present review we focus on new candidate genes susceptible for lung cancer, then examine all Japanese references by meta-analysis on susceptible genes over the past 20 years, and discuss whether new candidates and changing trend in Japan could be caused by environmental change.
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