Meroterpenoid, isocoumarin, and phenol derivatives from the seagrass-derived fungus Pestalotiopsis sp PSU-ES 194

Four new metabolites, including two meroterpenoids (1 and 2), an isocoumarin (3), and a phenol (4), have been isolated from the seagrass-derived fungus Pestalotiopsis sp. PSU-ES194 together with eight known compounds. Their structures were determined by extensive spectroscopic analysis. The bio-synthetic pathway for isolated meroterpenoids is proposed and employed to establish their absolute configurations. The isolated compounds were evaluated for antimicrobial, antimycobacterial, antimalarial, and cytotoxic activities. (C) 2014 Elsevier Ltd. All rights reserved.