4.4 Article

Temsirolimus-Induced Glomerulopathy

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ONCOLOGY
卷 76, 期 3, 页码 170-172

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KARGER
DOI: 10.1159/000201930

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Temsirolimus; Renal cell carcinoma; Proteinuria; Glomerulopathy; Podocyte

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A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5g/24h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion. Kidney biopsy revealed ischemic glomeruli and focal segmental glomerulosclerosis lesion. Proteinuria level decreased to 2.80 g per day two weeks after temsirolimus withdrawal. Clinicians should be aware to this complication. Copyright (C) 2009 S. Karger AG, Basel

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