期刊
TETRAHEDRON
卷 71, 期 34, 页码 5484-5493出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2015.06.078
关键词
Euphorbia dracunculoides; Diterpenoid; Lathyrane glycoside; Myrsinane; Tigliane
资金
- National Natural Science Foundation of China [21162044]
- High-end Science and Technology Talents Program of Yunnan Province, China [2013HA022]
- Mid-aged and Young Academic and Technical Leader Raising Foundation of Yunnan Province, China [2010CI040]
Extensive phytochemical investigation of the aerial parts of Euphorbia dracunculoides led to the isolation of 19 structurally diversified diterpenoids with five different carbon skeletons, including six new lathyrane glycosides (1-6), three new cyclomyrsinanes (7-9), three new premyrsinanes (10-12), and one new 10,18-dihydromyrsinane (13). Their structures were elucidated by means of extensive spectroscopic analysis, and the structure of 7 was further confirmed by X-ray crystallography. Compounds 1-6 are the first examples of C-17-glycosylated lathyrane diterpenoids. Selected isolates were evaluated for their cytotoxicity against five cancer cell lines. Only the tiglianes exhibited moderate activity. (C) 2015 Elsevier Ltd. All rights reserved.
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