期刊
TETRAHEDRON
卷 71, 期 41, 页码 7837-7841出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2015.08.024
关键词
Red Sea Verongid sponges; Pseudoceratina arabica; Brominated alkaloids; Ceratinines F-H; Antimigratory and antiproliferative activities; Metastatic breast cancer; HeLa cells
资金
- NSTIP strategic technologies program in the Kingdom of Saudi Arabia [11-BIO2056-03]
Three new dibrominated alkaloids, ceratinines F-H (2-4), together with the known compounds molokialamine (1), psammaplysin A (5), ceratinamide A (6), 19-hydroxyceratinamide A (7), psammaplysin E (8) and ceratinophenol A (9) were isolated from a new collection of the Red Sea marine sponge Pseudoceratina arabica. The structures of the isolated compounds were assigned by different spectral data including 1D and 2D NMR and HRMS. The compounds were evaluated for their antimigratory activity against the highly metastatic human breast cancer cell line MDA-MB-231 as well as for their antiproliferative activity against HeLa cells. Compound 8 showed potent antimigratory activity with IC50 value of 0.31 mu M, while 9 displayed moderate activity with IC50 of 10.4 mu M. In addition, compounds 4 and 8 showed potent antiproliferative activities against HeLa cells with IC50 values of 2.56 and 2.19 mu M, respectively. (c) 2015 Elsevier Ltd. All rights reserved.
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