4.8 Review

Cancer systems biology: embracing complexity to develop better anticancer therapeutic strategies

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Landscape of genomic alterations in cervical carcinomas

Akinyemi I. Ojesina et al.

NATURE (2014)

Article Multidisciplinary Sciences

Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers

Allison S. Cleary et al.

NATURE (2014)

Article Biotechnology & Applied Microbiology

Clinical development success rates for investigational drugs

Michael Hay et al.

NATURE BIOTECHNOLOGY (2014)

Article Multidisciplinary Sciences

Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

Brett E. Johnson et al.

SCIENCE (2014)

Review Oncology

Turning ecology and evolution against cancer

Kirill S. Korolev et al.

NATURE REVIEWS CANCER (2014)

Review Oncology

Macrophage Regulation of Tumor Responses to Anticancer Therapies

Michele De Palma et al.

CANCER CELL (2013)

Article Biochemistry & Molecular Biology

Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia

Dan A. Landau et al.

Article Biochemistry & Molecular Biology

Punctuated Evolution of Prostate Cancer Genomes

Sylvan C. Baca et al.

Article Biochemistry & Molecular Biology

Network quantification of EGFR signaling unveils potential for targeted combination therapy

Bertram Klinger et al.

MOLECULAR SYSTEMS BIOLOGY (2013)

Article Multidisciplinary Sciences

Comprehensivemolecular characterization of clear cell renal cell carcinoma

Chad J. Creighton et al.

NATURE (2013)

Article Multidisciplinary Sciences

Integrated genomic characterization of endometrial carcinoma

Gad Getz et al.

NATURE (2013)

Article Multidisciplinary Sciences

Signatures of mutational processes in human cancer

Ludmil B. Alexandrov et al.

NATURE (2013)

Article Biotechnology & Applied Microbiology

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

Jie Hu et al.

NATURE BIOTECHNOLOGY (2013)

Article Biotechnology & Applied Microbiology

Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing

Garrett M. Frampton et al.

NATURE BIOTECHNOLOGY (2013)

Review Cell Biology

p53 mutations in cancer

Patricia A. J. Muller et al.

NATURE CELL BIOLOGY (2013)

Article Genetics & Heredity

Emerging landscape of oncogenic signatures across human cancers

Giovanni Ciriello et al.

NATURE GENETICS (2013)

Review Biochemistry & Molecular Biology

Microenvironmental regulation of tumor progression and metastasis

Daniela F. Quail et al.

NATURE MEDICINE (2013)

Review Biochemistry & Molecular Biology

The quest to overcome resistance to EGFR-targeted therapies in cancer

Curtis R. Chong et al.

NATURE MEDICINE (2013)

Article Multidisciplinary Sciences

Impact of deleterious passenger mutations on cancer progression

Christopher D. McFarland et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

Andrea Sottoriva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Multidisciplinary Sciences

Epigenetic Reprogramming in Cancer

Mario L. Suva et al.

SCIENCE (2013)

Review Multidisciplinary Sciences

Cancer Genome Landscapes

Bert Vogelstein et al.

SCIENCE (2013)

Article Biochemistry & Molecular Biology

Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines

Mario Niepel et al.

SCIENCE SIGNALING (2013)

Article Biochemistry & Molecular Biology

Receptor Tyrosine Kinases Fall into Distinct Classes Based on Their Inferred Signaling Networks

Joel P. Wagner et al.

SCIENCE SIGNALING (2013)

Article Cell Biology

Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool

Song Ling Poon et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Cell Biology

Development of a Prognostic Model for Breast Cancer Survival in an Open Challenge Environment

Wei-Yi Cheng et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Multidisciplinary Sciences

RNA sequencing of cancer reveals novel splicing alterations

Jeyanthy Eswaran et al.

SCIENTIFIC REPORTS (2013)

Article Multidisciplinary Sciences

Novel Insights into Breast Cancer Genetic Variance through RNA Sequencing

Anelia Horvath et al.

SCIENTIFIC REPORTS (2013)

Article Multidisciplinary Sciences

Comprehensive identification of mutational cancer driver genes across 12 tumor types

David Tamborero et al.

SCIENTIFIC REPORTS (2013)

Article Biochemistry & Molecular Biology

A Whole-Cell Computational Model Predicts Phenotype from Genotype

Jonathan R. Karr et al.

Article Medicine, Research & Experimental

Exploiting Evolution To Treat Drug Resistance: Combination Therapy and the Double Bind

David Basanta et al.

MOLECULAR PHARMACEUTICS (2012)

Article Multidisciplinary Sciences

Passenger deletions generate therapeutic vulnerabilities in cancer

Florian L. Muller et al.

NATURE (2012)

Review Multidisciplinary Sciences

Clonal evolution in cancer

Mel Greaves et al.

NATURE (2012)

Article Multidisciplinary Sciences

Comprehensive molecular portraits of human breast tumours

Daniel C. Koboldt et al.

NATURE (2012)

Article Multidisciplinary Sciences

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

Ravid Straussman et al.

NATURE (2012)

Article Medicine, General & Internal

Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations

Keith T. Flaherty et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Medicine, General & Internal

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Marco Gerlinger et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Multidisciplinary Sciences

Transcriptomic landscape of breast cancers through mRNA sequencing

Jeyanthy Eswaran et al.

SCIENTIFIC REPORTS (2012)

Article Biochemical Research Methods

In silico Experimentation of Glioma Microenvironment Development and Anti-tumor Therapy

Yu Wu et al.

PLOS COMPUTATIONAL BIOLOGY (2012)

Review Oncology

The role of mutations in epigenetic regulators in myeloid malignancies

Alan H. Shih et al.

NATURE REVIEWS CANCER (2012)

Review Oncology

Intra-tumour heterogeneity: a looking glass for cancer?

Andriy Marusyk et al.

NATURE REVIEWS CANCER (2012)

Article Biochemistry & Molecular Biology

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

Philip J. Stephens et al.

Article Biochemistry & Molecular Biology

Genetic Interactions in Cancer Progression and Treatment

Alan Ashworth et al.

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Biochemistry & Molecular Biology

Deep sequencing reveals distinct patterns of DNA methylation in prostate cancer

Jung H. Kim et al.

GENOME RESEARCH (2011)

Article Biochemical Research Methods

Algorithms for Detecting Significantly Mutated Pathways in Cancer

Fabio Vandin et al.

JOURNAL OF COMPUTATIONAL BIOLOGY (2011)

Article Multidisciplinary Sciences

Genetic variegation of clonal architecture and propagating cells in leukaemia

Kristina Anderson et al.

NATURE (2011)

Article Multidisciplinary Sciences

Tumour evolution inferred by single-cell sequencing

Nicholas Navin et al.

NATURE (2011)

Article Multidisciplinary Sciences

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

Poulikos I. Poulikakos et al.

NATURE (2011)

Article Biotechnology & Applied Microbiology

Single-cell dissection of transcriptional heterogeneity in human colon tumors

Piero Dalerba et al.

NATURE BIOTECHNOLOGY (2011)

Article Genetics & Heredity

Increased methylation variation in epigenetic domains across cancer types

Kasper Daniel Hansen et al.

NATURE GENETICS (2011)

Review Oncology

Methodological and practical challenges for personalized cancer therapies

Ignacio I. Wistuba et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2011)

Article Medicine, General & Internal

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

Paul B. Chapman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Biochemistry & Molecular Biology

Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling

Y. Lu et al.

ONCOGENE (2011)

Article Multidisciplinary Sciences

Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis

Eun Sung Park et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Cell Biology

Personalized Oncology Through Integrative High-Throughput Sequencing: A Pilot Study

Sameek Roychowdhury et al.

SCIENCE TRANSLATIONAL MEDICINE (2011)

Article Multidisciplinary Sciences

Model for in vivo progression of tumors based on co-evolving cell population and vasculature

Sehyo C. Choe et al.

SCIENTIFIC REPORTS (2011)

Article Multidisciplinary Sciences

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

Peter J. Campbell et al.

NATURE (2010)

Article Multidisciplinary Sciences

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

Cory M. Johannessen et al.

NATURE (2010)

Review Oncology

The molecular pathology of cancer

Timothy J. R. Harris et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2010)

Review Genetics & Heredity

APPLICATIONS OF NEXT-GENERATION SEQUENCING Sequencing technologies - the next generation

Michael L. Metzker

NATURE REVIEWS GENETICS (2010)

Review Cell Biology

Genomic instability - an evolving hallmark of cancer

Simona Negrini et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Article Medicine, General & Internal

Gefitinib or Chemotherapy for Non-Small-Cell Lung Cancer with Mutated EGFR.

Makoto Maemondo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Biochemistry & Molecular Biology

Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases

Albrecht Moritz et al.

SCIENCE SIGNALING (2010)

Article Biochemistry & Molecular Biology

Predicting and controlling the reactivity of immune cell populations against cancer

Kfir Oved et al.

MOLECULAR SYSTEMS BIOLOGY (2009)

Article Multidisciplinary Sciences

Transcriptome sequencing to detect gene fusions in cancer

Christopher A. Maher et al.

NATURE (2009)

Article Biotechnology & Applied Microbiology

Genome-wide identification of post-translational modulators of transcription factor activity in human B cells

Kai Wang et al.

NATURE BIOTECHNOLOGY (2009)

Article Biochemistry & Molecular Biology

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging

Benjamin J. Vakoc et al.

NATURE MEDICINE (2009)

Article Multidisciplinary Sciences

MEK1 mutations confer resistance to MEK and B-RAF inhibition

Caroline M. Emery et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene

Sian Jones et al.

SCIENCE (2009)

Article Biochemical Research Methods

Tumor-Immune Interaction, Surgical Treatment, and Cancer Recurrence in a Mathematical Model of Melanoma

Steffen Eikenberry et al.

PLOS COMPUTATIONAL BIOLOGY (2009)

Article Multidisciplinary Sciences

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

Timothy J. Ley et al.

NATURE (2008)

Article Biochemistry & Molecular Biology

Stromal gene expression predicts clinical outcome in breast cancer

Greg Finak et al.

NATURE MEDICINE (2008)

Article Biochemical Research Methods

Reverse-phase protein lysate microarrays for cell signaling analysis

Brett Spurrier et al.

NATURE PROTOCOLS (2008)

Article Multidisciplinary Sciences

Competitive release and facilitation of drug-resistant parasites after therapeutic chemotherapy in a rodent malaria model

Andrew R. Wargo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Medicine, General & Internal

Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

Brian J. Druker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Article Biochemistry & Molecular Biology

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

Jesper V. Olsen et al.

Article Multidisciplinary Sciences

The consensus coding sequences of human breast and colorectal cancers

Tobias Sjoeblom et al.

SCIENCE (2006)

Article Medicine, General & Internal

Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer

MJ Piccart-Gebhart et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Multidisciplinary Sciences

Global histone modification patterns predict risk of prostate cancer recurrence

DB Seligson et al.

NATURE (2005)

Review Immunology

Feedback regulation of lymphocyte signalling

M Reth et al.

NATURE REVIEWS IMMUNOLOGY (2004)

Review Biochemistry & Molecular Biology

Cancer genes and the pathways they control

B Vogelstein et al.

NATURE MEDICINE (2004)

Article Multidisciplinary Sciences

A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma

G Wright et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Review Biochemistry & Molecular Biology

DNA methylation in cancer: too much, but also too little

M Ehrlich

ONCOGENE (2002)

Article Multidisciplinary Sciences

Mutations of the BRAF gene in human cancer

H Davies et al.

NATURE (2002)

Article Multidisciplinary Sciences

Gene expression profiling predicts clinical outcome of breast cancer

LJ van't Veer et al.

NATURE (2002)

Review Genetics & Heredity

TGF-β signaling in tumor suppression and cancer progression

R Derynck et al.

NATURE GENETICS (2001)

Article Multidisciplinary Sciences

The microenvironment of the tumour-host interface

LA Liotta et al.

NATURE (2001)

Article Medicine, General & Internal

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.

BJ Druker et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

Article Medicine, General & Internal

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

DJ Slamon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)