期刊
ONCOGENE
卷 34, 期 6, 页码 752-760出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2013.599
关键词
ZFP57; IGF2; anchorage-independent growth; HT1080; transformation
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Hokkoku Foundation for Cancer Research
- Cancer Research Institute, Kanazawa University
- Grants-in-Aid for Scientific Research [23591982] Funding Source: KAKEN
Several common biological properties between cancer cells and embryonic stem (ES) cells suggest the possibility that some genes expressed in ES cells might have important roles in cancer cell growth. The transcription factor ZFP57 is expressed in self-renewing ES cells and its expression level decreases during ES cell differentiation. This study showed that ZFP57 is involved in the anchorage-independent growth of human fibrosarcoma HT1080 cells in soft agar. ZFP57 overexpression enhanced, whereas knockdown suppressed, HT1080 tumor formation in nude mice. Furthermore, ZFP57 regulates the expression of insulin-like growth factor 2 (IGF2), which has a critical role in ZFP57-induced anchorage-independent growth. ZFP57 also promotes anchorage-independent growth in ES cells and immortal fibroblasts. Finally, immunohistochemical analysis revealed that ZFP57 is overexpressed in human cancer clinical specimens. Taken together, these results suggest that the ES-specific transcription factor ZFP57 is a novel oncogene.
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