4.8 Review

MDM2's social network

相关参考文献

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Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability

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Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase IVIDM2 activates the Notch signalling pathway

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Ribosomal protein S14 unties the MDM2-p53 loop upon ribosomal stress

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Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway

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Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1

Deresa Lee et al.

EMBO REPORTS (2012)

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Integration of DNA Damage and Repair with Murine Double-Minute 2 (Mdm2) in Tumorigenesis

Jason A. Lehman et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)

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An iTRAQ Proteomics Screen Reveals the Effects of the MDM2 Binding Ligand Nutlin-3 on Cellular Proteostasis

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JOURNAL OF PROTEOME RESEARCH (2012)

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MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells

L. Gu et al.

ONCOGENE (2012)

Article Cell Biology

Roles of COP9 signalosome in cancer

Mong-Hong Lee et al.

CELL CYCLE (2011)

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Interplay between Ribosomal Protein S27a and MDM2 Protein in p53 Activation in Response to Ribosomal Stress

Xiao-Xin Sun et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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Trp53 regulates Notch 4 signaling through Mdm2

Youping Sun et al.

JOURNAL OF CELL SCIENCE (2011)

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Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers

Ruiying Zhao et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

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MDM2 Regulates Vascular Endothelial Growth Factor mRNA Stabilization in Hypoxia

Sheng Zhou et al.

MOLECULAR AND CELLULAR BIOLOGY (2011)

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PKCδ Regulates Mdm2 Independently of p53 in the Apoptotic Response to DNA Damage

Hoi Chin Hew et al.

MOLECULAR CARCINOGENESIS (2011)

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Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

Trudy G. Oliver et al.

MOLECULAR CELL (2011)

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UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53

Hong Wu et al.

NATURE MEDICINE (2011)

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ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A

G. P. Shouse et al.

ONCOGENE (2011)

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Effects of the MDM2 promoter SNP285 and SNP309 on Sp1 transcription factor binding and cancer risk

Stian Knappskog et al.

TRANSCRIPTION-AUSTIN (2011)

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The molecular dynamics of MDM2

Judith Nicholson et al.

CELL CYCLE (2010)

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S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

Keng Po Lai et al.

EMBO JOURNAL (2010)

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MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output

Lihong Chen et al.

EMBO JOURNAL (2010)

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ATM Augments Nuclear Stabilization of DYRK2 by Inhibiting MDM2 in the Apoptotic Response to DNA Damage

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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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MDM2 Promotes Proteasomal Degradation of p21Waf1 via a Conformation Change

Hongxia Xu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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MDM2 Mediates Ubiquitination and Degradation of Activating Transcription Factor 3

Pingli Mo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice

Cho-Rok Jung et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

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Hdm2 negatively regulates telomerase activity by functioning as an E3 ligase of hTERT

W. Oh et al.

ONCOGENE (2010)

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RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage

Xiaoyong Fu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Cell Biology

The p53 orchestra: Mdm2 and Mdmx set the tone

Mark Wade et al.

TRENDS IN CELL BIOLOGY (2010)

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ALP/Enigma PDZ-LIM Domain Proteins in the Heart

Ming Zheng et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2010)

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Role of Mdm2 acid domain interactions in recognition and ubiquitination of the transcription factor IRF-2

Susanne Pettersson et al.

BIOCHEMICAL JOURNAL (2009)

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Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization

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CELL DEATH AND DIFFERENTIATION (2009)

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RYBP stabilizes p53 by modulating MDM2

Deng Chen et al.

EMBO REPORTS (2009)

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CK1α Plays a Central Role in Mediating MDM2 Control of p53 and E2F-1 Protein Stability

Anne-Sophie Huart et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Ribosomal Protein S7 Is Both a Regulator and a Substrate of MDM2

Yan Zhu et al.

MOLECULAR CELL (2009)

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p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

Shu-Ping Wang et al.

NATURE CELL BIOLOGY (2009)

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Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway

C. S. Busso et al.

ONCOGENE (2009)

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Acetylation is indispensable for p53 activation

Yi Tang et al.

Article Cell Biology

Specific inhibition of mdm2-mediated neddylation by tip60

Christoph Dohmesen et al.

CELL CYCLE (2008)

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Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26

Yaara Ofir-Rosenfeld et al.

MOLECULAR CELL (2008)

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p53 mrNA controls p53 activity by managing Mdm2 functions

Marco M. Candeias et al.

NATURE CELL BIOLOGY (2008)

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Mdm2 Induces Mono-Ubiquitination of FOXO4

Arjan B. Brenkman et al.

PLOS ONE (2008)

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Roles for negative cell regulator 14-3-3σ in control of MDM2 activities

H-Y Yang et al.

ONCOGENE (2007)

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Quantitative analyses reveal the importance of regulated Hdmx degradation for P53 activation

Yunyuan V. Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis

Cinzia Rinaldo et al.

MOLECULAR CELL (2007)

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An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

Stjepan Uldrijan et al.

EMBO JOURNAL (2007)

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Regulating the p53 pathway:: in vitro hypotheses, in vivo veritas

Franck Toledo et al.

NATURE REVIEWS CANCER (2006)

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Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53

Milka Kostic et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

Article Cell Biology

Critical role for Daxx in regulating Mdm2

Jun Tang et al.

NATURE CELL BIOLOGY (2006)

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Dual-site regulation of MDM2 E3-ubiquitin ligase activity

Maura Wallace et al.

MOLECULAR CELL (2006)

Article Biochemistry & Molecular Biology

p19ras interacts with and activates p73 by involving the MDM2 protein

MH Jeong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Molecular recognition of p53 and MDM2 by USP7/HAUSP

Y Sheng et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair

JR Alt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Biochemistry & Molecular Biology

A dynamic role of HAUSP in the p53-Mdm2 pathway

MY Li et al.

MOLECULAR CELL (2004)

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Inhibition of p53 degradation by Mdm2 acetylation

XJ Wang et al.

FEBS LETTERS (2004)

Article Biochemistry & Molecular Biology

The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression

N Minsky et al.

MOLECULAR CELL (2004)

Article Biochemistry & Molecular Biology

Yin Yang 1 is a negative regulator of p53

GC Sui et al.

Article Biochemistry & Molecular Biology

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

MS Dai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53

LK Linares et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Physical and functional interactions between PML and MDM2

XL Wei et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Multidisciplinary Sciences

Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor

L Girnita et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Oncology

Regulation of HDM2 activity by the ribosomal protein L11

MAE Lohrum et al.

CANCER CELL (2003)

Article Biochemistry & Molecular Biology

Nuclear localization of Y-box factor YB1 requires wild-type p53

YF Zhang et al.

ONCOGENE (2003)

Article Biochemistry & Molecular Biology

Stimulation of human DNA polymerase ε by MDM2

H Asahara et al.

NUCLEIC ACIDS RESEARCH (2003)

Article Biochemistry & Molecular Biology

Mammalian Numb is a target protein of Mdm2, ubiquitin ligase

S Yogosawa et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

Article Biochemistry & Molecular Biology

MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination

JC Badciong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes

Y Miyauchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

A Ito et al.

EMBO JOURNAL (2002)

Article Biochemistry & Molecular Biology

P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2

DP Xirodimas et al.

FEBS LETTERS (2002)

Article Biochemistry & Molecular Biology

MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation

YT Jin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation

Z Goldberg et al.

EMBO JOURNAL (2002)

Article Biochemistry & Molecular Biology

Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation

G Legube et al.

EMBO JOURNAL (2002)

Article Biochemistry & Molecular Biology

Cyclin G recruits PP2A to dephosphorylate Mdm2

K Okamoto et al.

MOLECULAR CELL (2002)

Article Biochemistry & Molecular Biology

The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63

V Calabrò et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Defining the molecular basis of Arf and Hdm2 interactions

B Bothner et al.

JOURNAL OF MOLECULAR BIOLOGY (2001)

Article Cell Biology

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

BHP Zhou et al.

NATURE CELL BIOLOGY (2001)

Article Biochemistry & Molecular Biology

Regulation of p63 function by Mdm2 and MdmX

M Kadakia et al.

DNA AND CELL BIOLOGY (2001)

Article Multidisciplinary Sciences

A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control

LM Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Multidisciplinary Sciences

MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins

E Kobet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Biochemistry & Molecular Biology

A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2

MT Boyd et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Biochemistry & Molecular Biology

MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase ε

N Vlatkovic et al.

NUCLEIC ACIDS RESEARCH (2000)