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ONCOGENE (2013)
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PLOS ONE (2013)
Golgi-SNARE GS28 potentiates cisplatin-induced apoptosis by forming GS28-MDM2-p53 complexes and by preventing the ubiquitination and degradation of p53
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BIOCHEMICAL JOURNAL (2012)
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CANCER CELL (2012)
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Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway
D. K. Thotala et al.
CELL DEATH AND DIFFERENTIATION (2012)
DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation
Yong-Sam Jung et al.
DNA REPAIR (2012)
Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1
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EMBO REPORTS (2012)
Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation
Nieves Embade et al.
HEPATOLOGY (2012)
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Jason A. Lehman et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
MDM2 Protein-mediated Ubiquitination of NUMB Protein IDENTIFICATION OF A SECOND PHYSIOLOGICAL SUBSTRATE OF MDM2 THAT EMPLOYS A DUAL-SITE DOCKING MECHANISM
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JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
An iTRAQ Proteomics Screen Reveals the Effects of the MDM2 Binding Ligand Nutlin-3 on Cellular Proteostasis
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JOURNAL OF PROTEOME RESEARCH (2012)
The cellular abundance of the essential transcription termination factor TTF-I regulates ribosome biogenesis and is determined by MDM2 ubiquitinylation
Frederic Lessard et al.
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MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells
L. Gu et al.
ONCOGENE (2012)
MDM2 interacts with NME2 (non-metastatic cells 2, protein) and suppresses the ability of NME2 to negatively regulate cell motility
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Interplay between Ribosomal Protein S27a and MDM2 Protein in p53 Activation in Response to Ribosomal Stress
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JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Hydrophilic Residues Are Crucial for Ribosomal Protein L11 (RPL11) Interaction with Zinc Finger Domain of MDM2 and p53 Protein Activation
Qi Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
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JOURNAL OF CELL SCIENCE (2011)
Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers
Ruiying Zhao et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
MDM2 Regulates Vascular Endothelial Growth Factor mRNA Stabilization in Hypoxia
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MOLECULAR AND CELLULAR BIOLOGY (2011)
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MOLECULAR CARCINOGENESIS (2011)
Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop
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MOLECULAR CELL (2011)
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
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NATURE (2011)
UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53
Hong Wu et al.
NATURE MEDICINE (2011)
Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator
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ONCOGENE (2011)
ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A
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ONCOGENE (2011)
Insulin Receptor Tyrosine Kinase Substrate Enhances Low Levels of MDM2-Mediated p53 Ubiquitination
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PLOS ONE (2011)
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TRANSCRIPTION-AUSTIN (2011)
Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFβ-TRCP Ubiquitin Ligase
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CANCER CELL (2010)
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CELL CYCLE (2010)
Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73
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CELL CYCLE (2010)
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EMBO JOURNAL (2010)
MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output
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EMBO JOURNAL (2010)
ATM Augments Nuclear Stabilization of DYRK2 by Inhibiting MDM2 in the Apoptotic Response to DNA Damage
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
MDM2 Promotes Proteasomal Degradation of p21Waf1 via a Conformation Change
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
MDM2 Mediates Ubiquitination and Degradation of Activating Transcription Factor 3
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice
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JOURNAL OF CLINICAL INVESTIGATION (2010)
Hdm2 negatively regulates telomerase activity by functioning as an E3 ligase of hTERT
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ONCOGENE (2010)
RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
The regulation of MDM2 by multisite phosphorylation-Opportunities for molecular-based intervention to target tumours?
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ALP/Enigma PDZ-LIM Domain Proteins in the Heart
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JOURNAL OF MOLECULAR CELL BIOLOGY (2010)
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BIOCHEMICAL JOURNAL (2009)
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CANCER CELL (2009)
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Mdm2 and PCAF increase Chk2 ubiquitination and degradation independently of their intrinsic E3 ligase activities
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CELL CYCLE (2009)
Guarding the guardian Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivo
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CELL CYCLE (2009)
Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization
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CELL DEATH AND DIFFERENTIATION (2009)
RYBP stabilizes p53 by modulating MDM2
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EMBO REPORTS (2009)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
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MOLECULAR CELL (2009)
p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug
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NATURE CELL BIOLOGY (2009)
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ONCOGENE (2009)
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CANCER RESEARCH (2008)
Acetylation is indispensable for p53 activation
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CELL (2008)
Specific inhibition of mdm2-mediated neddylation by tip60
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CELL CYCLE (2008)
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex
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EMBO JOURNAL (2008)
Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26
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MOLECULAR CELL (2008)
p53 mrNA controls p53 activity by managing Mdm2 functions
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NATURE CELL BIOLOGY (2008)
Mdm2 Induces Mono-Ubiquitination of FOXO4
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PLOS ONE (2008)
Roles for negative cell regulator 14-3-3σ in control of MDM2 activities
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ONCOGENE (2007)
The Wip1 phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop
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CANCER CELL (2007)
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CANCER CELL (2007)
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ONCOGENE (2007)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity
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CANCER RESEARCH (2007)
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ONCOGENE (2007)
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MOLECULAR CELL (2007)
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EMBO JOURNAL (2007)
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MOLECULAR AND CELLULAR BIOLOGY (2007)
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NATURE REVIEWS CANCER (2006)
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JOURNAL OF MOLECULAR BIOLOGY (2006)
Critical role for Daxx in regulating Mdm2
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NATURE CELL BIOLOGY (2006)
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CELL CYCLE (2006)
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MOLECULAR CELL (2006)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
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Y Sheng et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
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CELL (2005)
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H Higashitsuji et al.
CANCER CELL (2005)
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JR Alt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
A dynamic role of HAUSP in the p53-Mdm2 pathway
MY Li et al.
MOLECULAR CELL (2004)
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XJ Wang et al.
FEBS LETTERS (2004)
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition
MS Dai et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Protein kinase CK1δ phosphorylates key sites in the acidic domain of murine double-minute clone 2 protein (MDM2) that regulate p53 turnover
M Winter et al.
BIOCHEMISTRY (2004)
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1
CW Wu et al.
NATURE (2004)
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
GL Bond et al.
CELL (2004)
The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression
N Minsky et al.
MOLECULAR CELL (2004)
Yin Yang 1 is a negative regulator of p53
GC Sui et al.
CELL (2004)
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MS Dai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
LK Linares et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization
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Physical and functional interactions between PML and MDM2
XL Wei et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor
L Girnita et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Regulation of HDM2 activity by the ribosomal protein L11
MAE Lohrum et al.
CANCER CELL (2003)
Nuclear localization of Y-box factor YB1 requires wild-type p53
YF Zhang et al.
ONCOGENE (2003)
Stimulation of human DNA polymerase ε by MDM2
H Asahara et al.
NUCLEIC ACIDS RESEARCH (2003)
Mammalian Numb is a target protein of Mdm2, ubiquitin ligase
S Yogosawa et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination
JC Badciong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes
Y Miyauchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation
A Ito et al.
EMBO JOURNAL (2002)
P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2
DP Xirodimas et al.
FEBS LETTERS (2002)
MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation
YT Jin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase
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EMBO JOURNAL (2002)
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Z Goldberg et al.
EMBO JOURNAL (2002)
Alternative and aberrant splicing of MDM2 mRNA in human cancer
F Bartel et al.
CANCER CELL (2002)
MDM2 induces NF-κB/p65 expression transcriptionally through Sp1-binding sites:: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia
LB Gu et al.
BLOOD (2002)
Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation
G Legube et al.
EMBO JOURNAL (2002)
Cyclin G recruits PP2A to dephosphorylate Mdm2
K Okamoto et al.
MOLECULAR CELL (2002)
The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63
V Calabrò et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Defining the molecular basis of Arf and Hdm2 interactions
B Bothner et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
BHP Zhou et al.
NATURE CELL BIOLOGY (2001)
Regulation of p63 function by Mdm2 and MdmX
M Kadakia et al.
DNA AND CELL BIOLOGY (2001)
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
LM Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
MDM2 inhibits p300-mediated p53 acetylation and activation by forming a ternary complex with the two proteins
E Kobet et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2
MT Boyd et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
MDM2 interacts with the C-terminus of the catalytic subunit of DNA polymerase ε
N Vlatkovic et al.
NUCLEIC ACIDS RESEARCH (2000)