Efficient multi-component synthesis of 1,4-benzodiazepine-3,5-diones: a Petasis-based approach

A new design for the synthesis of 1,2-dihydro-4H-benzo[e][1,4]diazepine-3,5-diones based on Petasis reaction followed by intramolecular amidation in one-pot manner is reported. By employing different primary aromatic and aliphatic amines along with boronic acid derivatives, the desired products have been obtained at ambient temperature in moderate to good yields. (C) 2015 Elsevier Ltd. All rights reserved.