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Roy S. Herbst et al.
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J. S. Imam et al.
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C. R. Reis et al.
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Kirthan Shenoy et al.
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TM Ganten et al.
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RC Budd et al.
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S Martin et al.
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S Ray et al.
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M MacFarlane et al.
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P Horak et al.
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JM Cummins et al.
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ZY Jin et al.
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