期刊
ONCOGENE
卷 31, 期 40, 页码 4343-4352出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2011.603
关键词
pRb; E2F-1; phosphorylation; acetylation; methylation
资金
- CRUK
- MRC
- LRF
- EU
- AICR
- MRC [G1000807] Funding Source: UKRI
- Medical Research Council [G1000807] Funding Source: researchfish
The failure of cell proliferation to be properly regulated is a hallmark of tumourigenesis. The retinoblastoma protein (pRb) pathway represents a key component in the regulation of the cell cycle and tumour suppression. Recent findings have revealed new levels of complexity reflecting a repertoire of post-translational modifications that occur on pRb together with its key effector E2F-1. Here we provide an overview of the modifications and consider the possibility of a 'code' that endows pRb with the ability to function in diverse physiological settings. Oncogene (2012) 31, 4343-4352; doi: 10.1038/onc.2011.603; published online 16 January 2012
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据