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RUNX3 Inactivation in Colorectal Polyps Arising Through Different Pathways of Colonic Carcinogenesis
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Downregulation of RUNX1 by RUNX3 Requires the RUNX3 VWRPY Sequence and Is Essential for Epstein-Barr Virus-Driven B-Cell Proliferation
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Repression of Runx2 by Androgen Receptor (AR) in Osteoblasts and Prostate Cancer Cells: AR Binds Runx2 and Abrogates Its Recruitment to DNA
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RUNX1 mutations are frequent in chronic myelomonocytic leukemia and mutations at the C-terminal region might predict acute myeloid leukemia transformation
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Expression of RUNX3 gene, methylation status and clinicopathological significance in breast cancer and breast cancer cell lines
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Downregulation of the RUNX3 gene by promoter hypermethylation and hemizygous deletion in breast cancer
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RUNX1-RUNX1 homodimerization modulates RUNX1 activity and function
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Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment
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Downregulation of RUNX3 and TES by hypermethylation in glioblastoma
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Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2
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RUNX3 protein is overexpressed in human basal cell carcinomas
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Expression of RANKL/RANK/OPG in primary and metastatic human prostate cancer as markers of disease stage and functional regulation
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RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer
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CANCER RESEARCH (2006)
Expression of receptor activator of nuclear factor κβ ligand (RANKL) and tumour necrosis factor related, apoptosis inducing ligand (TRAIL) in breast cancer, and their relations with osteoprotegerin, oestrogen receptor, and clinicopathological variables
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Bone morphogenetic protein 7 protects prostate cancer cells from stress-induced apoptosis via both smad and c-jun NH2-terminal kinase pathways
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Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo
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Regulatory mechanisms controlling human E-cadherin gene expression
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ONCOGENE (2005)
DNA methylation-associated inactivation of TGFβ-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers
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BRITISH JOURNAL OF CANCER (2005)
A role for Runx2 in normal mammary gland and breast cancer bone metastasis
P Shore
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RUNX3 inactivation by point mutations and aberrant DNA methylation in bladder tumors
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CANCER RESEARCH (2005)
The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion
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Genes that mediate breast cancer metastasis to lung
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Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system
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NATURE (2005)
The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts
M Galindo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The RUNX genes: Gain or loss of function in cancer
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Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development
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JOURNAL OF CELLULAR PHYSIOLOGY (2005)
Transcriptional cross-regulation of RUNX1 by RUNX3 in human B cells
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ONCOGENE (2005)
Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer
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INTERNATIONAL JOURNAL OF CANCER (2005)
Somatic point mutations in RUNX1/CBFA2/AML1 are common in high-risk myelodysplastic syndrome, but not in myelofibrosis with myeloid metaplasia
DP Steensma et al.
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Mechanisms of disease: Mechanisms of bone metastasis
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Methylation of RUNX3 in various types of human cancers and premalignant stages of gastric carcinoma
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Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines
M Wada et al.
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High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia
H Harada et al.
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A differential gene expression profile reveals overexpression of RUNX1/AML1 in invasive endometrioid carcinoma
J Planagumà et al.
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Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma
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Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease
GL Barnes et al.
CANCER RESEARCH (2004)
Frequent loss of RUNX3 expression by promoter hypermethylation in gastric carcinoma
Y Oshimo et al.
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Growth regulation of gastric epithelial cells by Runx3
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Frequent amplification and rearrangement of chromosomal bands 6p12-p21 and 17p11.2 in osteosarcoma
CC Lau et al.
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The osteoblast transcription factor Runx2 is expressed in mammary epithelial cells and mediates osteopontin expression
CK Inman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A fluorescence in situ hybridization study of TEL-AML1 fusion gene in B-cell acute lymphoblastic leukemia (1984-2001)
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Repeated observation of breast tumor subtypes in independent gene expression data sets
T Sorlie et al.
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Prostate cancer expression of runt-domain transcription factor Runx2, a key regulator of osteoblast differentiation and function
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BLOOD CELLS MOLECULES AND DISEASES (2003)
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New genes involved in cancer identified by retroviral tagging
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High-throughput retroviral tagging to identify components of specific signaling pathways in cancer
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NATURE GENETICS (2002)
High bone resorption in adult aging Transgenic mice overexpressing Cbfa1/Runx2 in cells of the osteoblastic lineage
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MOLECULAR AND CELLULAR BIOLOGY (2002)
The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons
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EMBO JOURNAL (2002)
The common retroviral insertion locus Dsi1 maps 30 kilobases upstream of the P1 promoter of the murine Runx3/Cbfa3/Aml2 gene
M Stewart et al.
JOURNAL OF VIROLOGY (2002)
Causal relationship between the loss of RUNX3 expression and gastric cancer
QL Li et al.
CELL (2002)
In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis
J Michaud et al.
BLOOD (2002)
Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures
WG Liu et al.
JOURNAL OF CELL BIOLOGY (2001)
Molecular portraits of human breast tumours
CM Perou et al.
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Unliganded and liganded estrogen receptors protect against cancer invasion via different mechanisms
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