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Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment
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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
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IAP-targeted therapies for cancer
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IAP antagonists induce autoubiquitination of c-IAPs, NF-κB activation, and TNFα-dependent apoptosis
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IAP antagonists target cIAP1 to induce TNFα- dependent apoptosis
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CELL (2007)
Autocrine TNFα signaling renders human cancer cells susceptible to smac-mimetic-induced apoptosis
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Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
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Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer
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JOURNAL OF MEDICINAL CHEMISTRY (2004)
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
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