期刊
ONCOGENE
卷 32, 期 4, 页码 431-443出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2012.74
关键词
FOXC2; miR-520h; resveratrol; metastasis
资金
- National Science Council [NSC-2632-B-001-MY3, NSC 96-2320-B-004-MY2, NSC 97-2320-B-039-039-MY3, NSC 98-2815-C-039-082-B]
- National Health Research Institutes Grant from Taiwan [NHRI-EX98-9712BC, NHRI-EX99-9712BC, NHRI-EX100-9712BC]
- Department of Health, Executive Yuan Grant from Taiwan [DOH99-TD-G111-011]
- China Medical University [CMU96-220, CMU97-077, CMU97-277, CMU-99-NTU-08, CMU100-TS-06, DMR-101-014]
Resveratrol, a phytochemical found in various plants and Chinese herbs, is associated with multiple tumor-suppressing activities, has been tested in clinical trials. However, the molecular mechanisms involved in resveratrol-mediated tumor suppressing activities are not yet completely defined. Here, we showed that treatment with resveratrol inhibited cell mobility through induction of the mesenchymal-epithelial transition (MET) in lung cancer cells. We. also found that downregulation of FOXC2 (forkhead box C2) is critical for resveratrol-mediated suppression of tumor metastasis in an in vitro and in vivo models. We also identified a signal cascade, namely, resveratrol-vertical bar miRNA-520h-vertical bar PP2A/C-vertical bar Akt -> NF-kappa B -> FOXC2, in which resveratrol inhibited the expression of FOXC2 through regulation of miRNA-520h-mediated signal cascade. This study identified a new miRNA-520h-related signal cascade involved in resveratrol-mediated tumor suppression activity and provide the clinical significances of miR-520h, PP2A/C and FOXC2 in lung cancer patients. Our results indicated a functional link between resveratrol-mediated miRNA-520h regulation and tumor suppressing ability, and provide a new insight into the role of resveratrol-induced molecular and epigenetic regulations in tumor suppression. Oncogene (2013) 32, 431-443; doi:10.1038/onc.2012.74; published online 12 March 2012
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据