期刊
ONCOGENE
卷 31, 期 47, 页码 4960-4966出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2011.650
关键词
breast cancer; CPEB; microRNA; translational regulation; TWIST1
资金
- European Commission [LSHG-CT-2006-037900]
- Danish Cancer Society [DP08036]
TWIST1 is a highly conserved basic helix-loop-helix transcription factor that promotes epithelial-mesenchymal transition (EMT). Its misregulation has been observed in various types of tumors. Using the MCF-10A-series of cell lines that recapitulate the early stages of breast cancer formation and EMT, we found TWIST1 to be upregulated during EMT and downregulated early in carcinogenesis. The TWIST1 3'UTR contains putative regulatory elements, including miRNA target sites and two cytoplasmic polyadenylation elements (CPE). We found that miR-580, CPEB1, and CPEB2 act as negative regulators of TWIST1 expression in a sequence-specific and additive/cooperative manner.
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