期刊
TETRAHEDRON
卷 71, 期 22, 页码 3671-3679出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.10.064
关键词
Anti-HIV; Securinega alkaloid; Flueggea virosa; Fluevirosinine; Alkaloid oligomer
资金
- National Natural Science Foundation for Excellent Young Scientists of P. R. China [81322045]
- Youth Innovation Promotion Association of Chinese Academy of Sciences
An MS guided fractionation of the alkaloidal constituents of Flueggea virosa has yielded nine new Securinega alkaloid oligomers, fluevirosinines B-J (1-9). The absolute structures of these oligomers have been characterized on the basis of spectroscopic data and biogenetic consideration. Fluevirosinines B-E (1-4) are four tetramers with new connecting sequences or new oligomerizing patterns, and fluevirosinines G-J (6-9) represent the first examples of pentamers of the Securinega alkaloid family. Among these alkaloids, fluevirosinine B (1) showed the best anti-HIV activity with an EC50 value of 14.1 +/- 1.2 (C) 2014 Elsevier Ltd. All rights reserved.
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