4.8 Review

Checkpoint control and cancer

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Dynamics of the p53-Mdm2 feedback loop in individual cells

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Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells

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Wip1-deficient mice are resistant to common cancer genes

M Harrison et al.

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Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1

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Human claspin is required for replication checkpoint control

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Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents

Z Xiao et al.

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The Chk2 tumor suppressor is not required for p53 responses in human cancer cells

PV Jallepalli et al.

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

L Zou et al.

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Chk2 activates E2F-1 in response to DNA damage

C Stevens et al.

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Chk1 and Chk2 kinases in checkpoint control and cancer

J Bartek et al.

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Phosphorylation of threonine 210 and the role of serine 137 in the regulation of mammalian polo-like kinase

YJ Jang et al.

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Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

H Zhao et al.

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

H Takai et al.

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Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

MT Jack et al.

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Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

DV Bulavin et al.

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Plk1 promotes nuclear translocation of human Cdc25C during prophase

F Toyoshima-Morimoto et al.

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Cdc25B activity is regulated by 14-3-3

A Forrest et al.

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Article Multidisciplinary Sciences

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

DV Bulavin et al.

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Rapid destruction of human Cdc25A in response to DNA damage

N Mailand et al.

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

A Hirao et al.

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Polo-like kinase-1 is a target of the DNA damage checkpoint

VAJ Smits et al.

NATURE CELL BIOLOGY (2000)