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Caveolae Mediate Growth Factor-induced Disassembly of Adherens Junctions to Support Tumor Cell Dissociation
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Src-Induced Disassembly of Adherens Junctions Requires Localized Phosphorylation and Degradation of the Rac Activator Tiam1
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MOLECULAR CELL (2009)
A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways
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Involvement of Members of the Cadherin Superfamily in Cancer
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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)
Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton
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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)
Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway
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MOLECULAR AND CELLULAR BIOLOGY (2008)
Cadherins and cancer: how does cadherin dysfunction promote tumor progression?
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Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2)
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TRAFFIC (2008)
Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src-mediated pathway
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Cell surface levels of organellar Na+/H+ exchanger isoform 6 are regulated by interaction with RACK1
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Derailed endocytosis: an emerging feature of cancer
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RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility
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Making and breaking contacts: the cellular biology of cadherin regulation
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RACK1 regulates Src activity and modulates paxillin dynamics during cell migration
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RACK1 inhibits colonic cell growth by regulating Src activity at cell cycle checkpoints
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ONCOGENE (2007)
RACK1 competes with HSP90 for binding to HIF-1α and is required for O2-independent and HSP90 inhibitor-induced degradation of HIF-1α
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Raf plus TGFβ-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin
E. Janda et al.
ONCOGENE (2006)
Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition
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Regulation of cadherin-mediated adhesion in morphogenesis
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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Lysosomal targeting of E-cadherin: a unique mechanism for the down-regulation of cell-cell adhesion during epithelial to mesenchymal transitions
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ONCOGENE (2004)
RACK1 and stratifin target ΔNp63α for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage
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Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition
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α3β1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPμ, expression and cell-cell adhesion
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MOLECULAR BIOLOGY OF THE CELL (2003)
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion
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ONCOGENE (2002)
Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling
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NATURE CELL BIOLOGY (2002)
Expression of the receptor protein-tyrosine phosphatase, PTPμ, restores E-cadherin-dependent adhesion in human prostate carcinoma cells
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
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The interaction of Src and RACK1 is enhanced by activation of protein kinase C and tyrosine phosphorylation of RACK1
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The PTPμ protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts
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N-cadherin extracellular repeat 4 mediates epithelial to mesenchymal transition and increased motility
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