相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。PTEN Level in Tumor Suppression: How Much Is Too Little?
Arkaitz Carracedo et al.
CANCER RESEARCH (2011)
Regulation of Protein Kinase C function by phosphorylation on conserved and non-conserved sites
Michael Freeley et al.
CELLULAR SIGNALLING (2011)
Cell-to-Cell Variability in PI3K Protein Level Regulates PI3K-AKT Pathway Activity in Cell Populations
Tina L. Yuan et al.
CURRENT BIOLOGY (2011)
Anovel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma
Guellue Goerguen et al.
BLOOD (2010)
Protein Kinase Cι Is Required for Pancreatic Cancer Cell Transformed Growth and Tumorigenesis
Michele L. Scotti et al.
CANCER RESEARCH (2010)
Quantitative assessment of markers for cell senescence
Conor Lawless et al.
EXPERIMENTAL GERONTOLOGY (2010)
Coordination of glioblastoma cell motility by PKCi
R. Mitchell Baldwin et al.
MOLECULAR CANCER (2010)
MLN8054, an Inhibitor of Aurora A Kinase, Induces Senescence in Human Tumor Cells Both In vitro and In vivo
Jessica J. Huck et al.
MOLECULAR CANCER RESEARCH (2010)
Feedback between p21 and reactive oxygen production is necessary for cell senescence
Joao F. Passos et al.
MOLECULAR SYSTEMS BIOLOGY (2010)
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
Hui-Kuan Lin et al.
NATURE (2010)
The nuts and bolts of AGC protein kinases
Laura R. Pearce et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
Krishna M. Vasudevan et al.
CANCER CELL (2009)
PIK3CA and PIK3CB Inhibition Produce Synthetic Lethality when Combined with Estrogen Deprivation in Estrogen Receptor-Positive Breast Cancer
Robert J. Crowder et al.
CANCER RESEARCH (2009)
BrafV600E cooperates with Pten loss to induce metastatic melanoma
David Dankort et al.
NATURE GENETICS (2009)
Protocols to detect senescence-associated beta-galactosidase (SA-beta gal) activity, a biomarker of senescent cells in culture and in vivo
Florence Debacq-Chainiaux et al.
NATURE PROTOCOLS (2009)
Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation
David A. Gewirtz et al.
BIOCHEMICAL PHARMACOLOGY (2008)
The Polarity Protein Par6 Induces Cell Proliferation and Is Overexpressed in Breast Cancer
Marissa E. Nolan et al.
CANCER RESEARCH (2008)
Small-Molecule Inhibitors of PDK1
Christian Peifer et al.
CHEMMEDCHEM (2008)
The overexpression and altered localization of the atypical protein kinase C λ/ι in breast cancer correlates with the pathologic type of these tumors
Yasuyuki Kojima et al.
HUMAN PATHOLOGY (2008)
Regulation of glioblastoma cell invasion by PKCι and RhoB
R. M. Baldwin et al.
ONCOGENE (2008)
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
Chi-Hwa Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Protein kinase Cι:: Human oncogene, prognostic marker and therapeutic target
Alan P. Fields et al.
PHARMACOLOGICAL RESEARCH (2007)
Restoration of p53 function leads to tumour regression in vivo
Andrea Ventura et al.
NATURE (2007)
Aurora-A: the maker and breaker of spindle poles
Alexis R. Barr et al.
JOURNAL OF CELL SCIENCE (2007)
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
Raffaella Di Micco et al.
NATURE (2006)
Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway
Christophe Denoyelle et al.
NATURE CELL BIOLOGY (2006)
Integrative genomic analysis of protein kinase C (PKC) family identifies PKCι as a biomarker and potential oncogene in ovarian carcinoma
Lin Zhang et al.
CANCER RESEARCH (2006)
Protection of glioblastoma cells from cisplatin cytotoxicity via protein kinase Cι-mediated attenuation of p38 MAP kinase signaling
R. M. Baldwin et al.
ONCOGENE (2006)
Mutation of the PIK3CA oncogene in human cancers
B Karakas et al.
BRITISH JOURNAL OF CANCER (2006)
Protein kinase Cι promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of μ- and m-calpains
LJ Xu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells
SJ Isakoff et al.
CANCER RESEARCH (2005)
Atypical protein kinase Cι, is an oncogene in human non-small cell lung cancer
RP Regala et al.
CANCER RESEARCH (2005)
Atypical PKCι contributes to poor prognosis through loss of apical-basal polarity and Cyclin E overexpression in ovarian cancer
AM Eder et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
ZB Chen et al.
NATURE (2005)
BRAFE600-associated senescence-like cell cycle arrest of human naevi
C Michaloglou et al.
NATURE (2005)
PHLPP: A phosphatase that directly dephosphorylates akt, promotes apoptosis, and suppresses tumor growth
TY Gao et al.
MOLECULAR CELL (2005)
VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
EA Harrington et al.
NATURE MEDICINE (2004)
Atypical protein kinase C (PKCζ/λ) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways
M Kanzaki et al.
JOURNAL OF CELL BIOLOGY (2004)
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
DJ Baker et al.
NATURE GENETICS (2004)
A DNA damage checkpoint response in telomere-initiated senescence
FD di Fagagna et al.
NATURE (2003)
High frequency of BRAF mutations in nevi
PM Pollock et al.
NATURE GENETICS (2003)
PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein
MT Scott et al.
EMBO JOURNAL (2002)
Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1
M Collado et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Cζ (PKCζ) and PKC-related kinase 2 by PDK1
A Balendran et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Targeting retrovirus to cancer cells expressing a mutant EGF receptor by insertion of a single chain antibody variable domain in the envelope glycoprotein receptor binding lobe
IAJ Lorimer et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2000)
The PI3K-PDK1 connection: more than just a road to PKB
B Vanhaesebroeck et al.
BIOCHEMICAL JOURNAL (2000)
分享论文
