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Eamonn R. Maher et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2011)
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von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish
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DISEASE MODELS & MECHANISMS (2010)
The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
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JOURNAL OF CLINICAL INVESTIGATION (2010)
Drosophila von Hippel-Lindau Tumor Suppressor Gene Function in Epithelial Tubule Morphogenesis
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MOLECULAR AND CELLULAR BIOLOGY (2010)
Dose-dependent modulation of HIF-1α/sima controls the rate of cell migration and invasion in Drosophila ovary border cells
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Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia
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BLOOD (2009)
Treatment of Kidney Cancer Insights Provided by the VHL Tumor-Suppressor Protein
William G. Kaelin
CANCER (2009)
von Hippel-Lindau tumor suppressor gene-dependent mRNA stabilization of the survival factor parathyroid hormone-related protein in human renal cell carcinoma by the RNA-binding protein HuR
Sabrina Danilin et al.
CARCINOGENESIS (2009)
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
Francesco Colotta et al.
CARCINOGENESIS (2009)
Inflammation and colorectal cancer
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CURRENT OPINION IN PHARMACOLOGY (2009)
Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia
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DEVELOPMENTAL BIOLOGY (2009)
The von Hippel Lindau Tumor Suppressor Limits Longevity
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The role of VHL in clear-cell renal cell carcinoma and its relation to targeted therapy
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MOLECULAR AND CELLULAR BIOCHEMISTRY (2009)
The Drosophila Metastasis Suppressor Gene Nm23 Homolog, awd, Regulates Epithelial Integrity during Oogenesis
Julie A. Woolworth et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Regulation of Renal Epithelial Tight Junctions by the von Hippel-Lindau Tumor Suppressor Gene Involves Occludin and Claudin 1 and Is Independent of E-Cadherin
Sarah K. Harten et al.
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VHL loss causes spindle misorientation and chromosome instability
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Regulation of endocytosis via the oxygen-sensing pathway
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NATURE MEDICINE (2009)
Molecular mechanisms of mTOR-mediated translational control
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The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIMEL
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ONCOGENE (2009)
Deciphering von Hippel-Lindau (VHL/Vhl)-Associated Pancreatic Manifestations by Inactivating Vhl in Specific Pancreatic Cell Populations
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PLOS ONE (2009)
Endothelial function of von Hippel-Lindau tumor suppressor gene: Control of fibroblast growth factor receptor signaling
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CANCER RESEARCH (2008)
The VHL tumor suppressor and HIF: insights from genetic studies in mice
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CELL DEATH AND DIFFERENTIATION (2008)
Cell autonomy of HIF effects in Drosophila:: Tracheal cells sense hypoxia and induce terminal branch sprouting
Lazaro Centanin et al.
DEVELOPMENTAL CELL (2008)
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation
Ian J. Frew et al.
EMBO JOURNAL (2008)
pVHL is a regulator of glucose metabolism and insulin secretion in pancreatic β cells
Jens Zehetner et al.
GENES & DEVELOPMENT (2008)
Inadequate Activation of the GTPase RhoA Contributes to the Lack of Fibronectin Matrix Assembly in von Hippel-Lindau Protein-defective Renal Cancer Cells
Monica Feijoo-Cuaresma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Combined Vhlh and Pten mutation causes genital tract cystadenoma and squamous metaplasia
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MOLECULAR AND CELLULAR BIOLOGY (2008)
The von hippel-lindau tumor suppressor protein and Egl-9-type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress
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MOLECULAR AND CELLULAR BIOLOGY (2008)
awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion
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MOLECULAR AND CELLULAR BIOLOGY (2008)
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400
Arthur P. Young et al.
NATURE CELL BIOLOGY (2008)
pVHL: A Multipurpose Adaptor Protein
Ian J. Frew et al.
SCIENCE SIGNALING (2008)
Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2
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ONCOGENE (2008)
Stable expression of HIF-1α in tubular epithelial cells promotes interstitial fibrosis
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AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2008)
Multitasking by pVHL in tumour suppression
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CURRENT OPINION IN CELL BIOLOGY (2007)
pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-κB agonist Card9 by CK2
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MOLECULAR CELL (2007)
Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular disease
Kirsten Brukamp et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2007)
Sequential pulses of apical epithelial secretion and endocytosis drive airway maturation in Drosophila
Vasilios Tsarouhas et al.
DEVELOPMENTAL CELL (2007)
Wurst is essential for airway clearance and respiratory-tube size control
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NATURE CELL BIOLOGY (2007)
pVHL and GSK3β are components of a primary cilium-maintenance signalling network
Claudio R. Thoma et al.
NATURE CELL BIOLOGY (2007)
von Hippel-Lindau disease-associated hemangioblastomas are derived from embryologic multipotent cells
Deric M. Park et al.
PLOS MEDICINE (2007)
The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer
Daniel Cho et al.
CLINICAL CANCER RESEARCH (2007)
The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth
Bernhard Schermer et al.
JOURNAL OF CELL BIOLOGY (2006)
Generation of noncentrosomal microtubule arrays
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JOURNAL OF CELL SCIENCE (2006)
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer
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NATURE REVIEWS DRUG DISCOVERY (2006)
Hypoxia-induced pulmonary vascular remodeling - Cellular and molecular mechanisms
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CIRCULATION RESEARCH (2006)
Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology
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PLOS MEDICINE (2006)
Vascular defects and liver damage by the acute inactivation of the VHL gene during mouse embryogenesis
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LABORATORY INVESTIGATION (2006)
Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein
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JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility
T Hsu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
pVHL function is essential for endothelial extracellular matrix deposition
N Tang et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
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Rend cyst development in mice with conditional inactivation of the von Hippel-Lindau tumor suppressor
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CANCER RESEARCH (2006)
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CANCER RESEARCH (2006)
Analysis of the hypoxia-sensing pathway in Drosophila melanogaster
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BIOCHEMICAL JOURNAL (2006)
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
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NATURE MEDICINE (2006)
Role of elongin-binding domain of von Hippel Lindau gene product on HuR-mediated VPF/VEGF mRNA stability in renal cell carcinoma
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ONCOGENE (2005)
Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans
C Shen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Phosphorylation-induced autoinhibition regulates the cytoskeletal protein lethal (2) giant larvae
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KIDNEY INTERNATIONAL (2004)
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes
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MOLECULAR AND CELLULAR BIOLOGY (2004)
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PLOS BIOLOGY (2004)
Congenital disorder of oxygen sensing:: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors
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BLOOD (2004)
Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development
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DEVELOPMENT (2004)
Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development
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Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
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NATURE (2003)
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EMBO JOURNAL (2003)
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DEVELOPMENT (2003)
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ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2003)
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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL
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NATURE CELL BIOLOGY (2003)
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TRENDS IN CELL BIOLOGY (2002)
HIF activation identifies early lesions in VHL kidneys: Evidence for site-specific tumor suppressor function in the nephron
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CELL (2001)
C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
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CELL (2001)
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SCIENCE (2001)
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SCIENCE (2001)
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
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