期刊
ONCOGENE
卷 29, 期 12, 页码 1717-1719出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2009.519
关键词
Beclin 1; autophagy; apoptosis
资金
- EU
- Ligue contre le Cancer
- Agence Nationale pour la Recherche
- Institut National sur le Cancer
- Canceropole Ile-de-France
- Fondation pour la Recherche Medicale
Beclin 1 has a key role in the initiation of autophagy, a process of self-cannibalism in which cytoplasmic constituents are sequestered and targeted for lysosomal degradation. In a recent issue of Cell Death & Disease, Wirawan et al. report the significant finding that caspases can cleave Beclin 1, thereby destroying its pro-autophagic activity. Moreover, the C-terminal fragment of Beclin 1 that results from this cleavage acquires a new function and can amplify mitochondrion-mediated apoptosis. Of note, the BH3 domain of Beclin 1 remains within the N-terminal fragment, which has no detectable pro-apoptotic activity. These findings provide important insights into the molecular cross talk between autophagy and apoptosis. Oncogene (2010) 29, 1717-1719; doi:10.1038/onc.2009.519; published online 25 January 2010
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据