期刊
ONCOGENE
卷 29, 期 32, 页码 4555-4566出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2010.213
关键词
prostate cancer; proteomics; collapsin response mediator protein-4; metastasis-suppressor gene; methylation
资金
- Chinese National Natural Science Foundation [30772178, 30973011, 30901496]
- Guangdong Provincial Science and Technology Research [7117362]
- Chinese Ministry of Health
- Chinese National Hi-Tech Research and Development Program [2007AA021906]
Metastasis is the chief cause of mortality from cancer, but the mechanisms leading to metastasis are poorly understood. We used a proteomics approach to screen for metastasis-associated proteins and found that collapsin response mediator protein-4 (CRMP4) expression was inversely associated with the lymph node metastasis of prostate cancer (PCa). Subsequent in vitro and in vivo studies revealed that overexpression of CRMP4 not only suppressed the invasion ability of PCa cells, but also strongly inhibited tumor metastasis in an animal model. Furthermore, methylation of a CpG island within the promoter region of the CRMP4 gene is responsible for downregulation of CRMP4 expression. Thus, in this study, we show new function of CRMP4 as a metastasis-suppressor in PCa. The findings provide new mechanistic insights into metastasis and therapeutic potential for this most common male cancer. Oncogene (2010) 29, 4555-4566; doi: 10.1038/onc.2010.213; published online 14 June 2010
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