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P21-activated kinase is required for mitotic progression and regulates Plk1
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Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins
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Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family wase, Chp
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Changes in the balance between caldesmon regulated by p21-activated kinases and the Arp2/3 complex govern podosome formation
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Phosphorylation of cortactin by p21-activated kinase
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Multiple Rho proteins regulate the subcellular targeting of PAK5
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A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases
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PAK1 hyperactivation is sufficient for mammary gland tumor formation
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Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties
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P21-activated kinase 1 regulation of estrogen receptor-α activation involves serine 305 activation linked with serine 118 phosphorylation
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LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase-type plasminogen activator system
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Inhibition of cap-dependent translation via phosphorylation of eIF4G by protein kinase Pak2
J Ling et al.
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Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141
JH Jung et al.
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Pak4 induces premature senescence via a pathway requiring p16INK4/P19ARF and mitogen-activated protein kinase signaling
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The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A
ZS Zhao et al.
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Binding of activated α2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK
UK Misra et al.
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Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3
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Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein
HM Cho et al.
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Nuclear localization and chromatin targets of p21-activated kinase 1
RR Singh et al.
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p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B
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PAK4 mediates morphological changes through the regulation of GEF-H1
MG Callow et al.
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Activation of gef-h1, a guanine nucleotide exchange factor for RhoA, by DNA transfection
M Brecht et al.
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Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control
BL Lua et al.
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Roles of the transcription factors snail and slug during mammary morphogenesis and breast carcinoma progression
C Côme et al.
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Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1
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Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts
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p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrate
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Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2
MA Koeppel et al.
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The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK
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EMBO JOURNAL (2004)
The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation
H He et al.
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Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes
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Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation
R Jakobi et al.
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p21-activated kinase 2 in neutrophils can be regulated by phosphorylation at multiple sites and by a variety of protein phosphatases
Q Zhan et al.
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PAK4 kinase is essential for embryonic viability and for proper neuronal development
J Qu et al.
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Targeted disruption of the gene for the PAK5 kinase in mice
XF Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
LIM kinase 1 is essential for the invasive growth of prostate epithelial cells - Implications in prostate cancer
M Davila et al.
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X-linked mild non-syndromic mental retardation with neuropsychiatric problems and the missense mutation A365E in PAK3
AK Gedeon et al.
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p21-activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD
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A role for LIM kinase in cancer invasion
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The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis
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Essential functions of p21-activated kinase 1 in morphogenesis and differentiation of mammary glands
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A new constitutively active brain PAK3 isoform displays modified specificities toward Rac and Cdc42 GTPases
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Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells
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Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4
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Akt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migration
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Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1
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p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells
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Pak1 phosphorylation on T212 affects microtubules in cells undergoing mitosis
M Banerjee et al.
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Cell cycle-regulated phosphorylation of p21-activated kinase 1
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Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain
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Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton
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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
P Bouillet et al.
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The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family
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p21-activated kinase links Rac/Cdc42 signaling to merlin.
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Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines
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AR and ER interaction with a p21-activated kinase (PAK6)
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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells
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Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the Ras guanine nucleotide exchange factor CDC25Mm/Ras-GRF1
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Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin
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The mechanism of PAK activation - Autophosphorylation events in both regulatory and kinase domains control activity
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p21-activated protein kinase γ-PAK suppresses programmed cell death of BALB3T3 fibroblasts
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Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6
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Activated PAK4 regulates cell adhesion and anchorage-independent growth
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Interaction of paxillin with p21-activated kinase (PAK) -: Association of paxillin α with the kinase-inactive and the Cdc42-activated forms of PAK3
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Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells
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