相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)
Shinichi Kitada et al.
BLOOD (2008)
Bcl-2-family proteins and hematologic malignancies: history and future prospects
John C. Reed
BLOOD (2008)
Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor anglogenesis in transgene-induced mammary tumor development
Dezheng Dong et al.
CANCER RESEARCH (2008)
Autophagy in the pathogenesis of disease
Beth Levine et al.
CELL (2008)
Bcl-B expression in human epithelial and nonepithelial malignancies
Maryla Krajewska et al.
CLINICAL CANCER RESEARCH (2008)
Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas
Hua-chuan Zheng et al.
HUMAN PATHOLOGY (2008)
BI-1 regulates endoplasmic reticulum Ca2+ Homeostasis downstream of bcl-2 family proteins
Chunyan Xu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Protein kinase Cθ is required for autophagy in response to stress in the endoplasmic reticulum
Kenjiro Sakaki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Dual role of proapoptotic BAD in insulin secretion and beta cell survival
Nika N. Danial et al.
NATURE MEDICINE (2008)
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
Jerry E. Chipuk et al.
TRENDS IN CELL BIOLOGY (2008)
Lucifer's labyrinth - Ten years of path finding in cell death
Pascal Meier et al.
MOLECULAR CELL (2007)
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
Mai Nguyen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival
Siamak Daneshmand et al.
HUMAN PATHOLOGY (2007)
mir-29 regulates Mcl-1 protein expression and apoptosis
J. L. Mott et al.
ONCOGENE (2007)
2-Methoxy antimycin reveals a unique mechanism for Bcl-xL inhibition
Pamela S. Schwartz et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Signal integration in the endoplasmic reticulum unfolded protein response
David Ron et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
ER stress triggers apoptosis by activating BH3-only protein Bim
Hamsa Puthalakath et al.
CELL (2007)
In vitro evaluation of the anticancer effect of lactoferrin and tea polyphenol combination on oral carcinoma cells
K. V. P. Chandra Mohan et al.
CELL BIOLOGY INTERNATIONAL (2007)
Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma
Frederic Luciano et al.
BLOOD (2007)
Bcl-2 and Bcl-XL regulate proinf lammatory caspase-1 activation by interaction with NALP1
Jean-Marie Bruey et al.
CELL (2007)
Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia
Susan O'Brien et al.
JOURNAL OF CLINICAL ONCOLOGY (2007)
Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-β, and Bcl-2
Maria Hoyer-Hansen et al.
MOLECULAR CELL (2007)
Mitochondrial membrane permeabilization in cell death
Guido Kroemer et al.
PHYSIOLOGICAL REVIEWS (2007)
Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: The oblimersen melanoma study group
Agop Y. Bedikian et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
Shida Yousefi et al.
NATURE CELL BIOLOGY (2006)
Prognostic significance of the Epstein-Barr virus, p53, Bcl-2, and survivin in nasopharyngeal cancer
Kenneth W. Yip et al.
CLINICAL CANCER RESEARCH (2006)
Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities
J. C. Reed
CELL DEATH AND DIFFERENTIATION (2006)
Bcl2's flexible loop domain regulates p53 binding and survival
Xingming Deng et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt
Y-H Han et al.
ONCOGENE (2006)
The mitochondrial permeability transition from in vitro artifact to disease target
P Bernardi et al.
FEBS JOURNAL (2006)
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1α
C Hetz et al.
SCIENCE (2006)
The colorectal microRNAome
JM Cummins et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis
TG Bivona et al.
MOLECULAR CELL (2006)
Role of the unfolded protein response in cell death
R Kim et al.
APOPTOSIS (2006)
A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
GA Calin et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Endoplasmic reticulum stress: cell life and death decisions
CY Xu et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
miR-15 and miR-16 induce apoptosis by targeting BCL2
A Cimmino et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
S Pattingre et al.
CELL (2005)
Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin
F Edlich et al.
EMBO JOURNAL (2005)
Apoptosis-based therapies for hematologic malignancies
JC Reed et al.
BLOOD (2005)
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T Oltersdorf et al.
NATURE (2005)
Autophagy in metazoans: Cell survival in the land of plenty
JJ Lum et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Autophagy: Dual roles in life and death?
EH Baehrecke
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Stabilization and enhancement of the antiapoptotic activity of Mcl-1 by TCTP
H Liu et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
The role of BH3-only proteins in the immune system
A Strasser
NATURE REVIEWS IMMUNOLOGY (2005)
Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-XL
B Becattini et al.
CHEMISTRY & BIOLOGY (2004)
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3
BZ Lin et al.
CELL (2004)
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
JE Chipuk et al.
SCIENCE (2004)
Bcl-XL mutations suppress cellular sensitivity to antimycin A
MK Manion et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
LD Walensky et al.
SCIENCE (2004)
Activating transcription factor 4 is translationally regulated by hypoxic stress
JD Blais et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
DAP-kinase as a target for drug design in cancer and diseases associated with accelerated cell death
S Bialik et al.
SEMINARS IN CANCER BIOLOGY (2004)
The pathophysiology of mitochondrial cell death
DR Green et al.
SCIENCE (2004)
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
S Shimizu et al.
NATURE CELL BIOLOGY (2004)
Death by design: apoptosis, necrosis and autophagy
AL Edinger et al.
CURRENT OPINION IN CELL BIOLOGY (2004)
Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: New avenues for cancer chemoprevention and chemotherapy
M Pellecchia et al.
CURRENT PHARMACEUTICAL DESIGN (2004)
Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis
G Szabadkai et al.
MOLECULAR CELL (2004)
Regulation of apoptosis by endoplasmic reticulum pathways
DG Breckenridge et al.
ONCOGENE (2003)
The Bcl-2 family: roles in cell survival and oncogenesis
S Cory et al.
ONCOGENE (2003)
Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distance
MJ Thomenius et al.
JOURNAL OF CELL SCIENCE (2003)
Regulation of cell death: The calcium-apoptosis link
S Orrenius et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
BAX and BAK regulation of endoplasmic reticulum Ca2+:: A control point for apoptosis
L Scorrano et al.
SCIENCE (2003)
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
J Yu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Chemotherapy: targeting the mitochondrial cell death pathway
KM Debatin et al.
ONCOGENE (2002)
The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases.
G Shohat et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2002)
BID regulation by p53 contributes to chemosensitivity
JK Sax et al.
NATURE CELL BIOLOGY (2002)
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane
T Kuwana et al.
CELL (2002)
The triterpenoid CDDO induces apoptosis in refractory CLL B cells
IM Pedersen et al.
BLOOD (2002)
Development of a potent Bcl-xL antagonist based on α-helix mimicry
O Kutzki et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
A Letai et al.
CANCER CELL (2002)
Bcl-XL affects Ca2+ horneostasis by altering expression of inositol 1,4,5-trisphosphate receptors
C Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Oblimersen bcl-2 antisense: Facilitating apoptosis in anticancer treatment
RJ Klasa et al.
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT (2002)
Apoptosis-based therapies
JC Reed
NATURE REVIEWS DRUG DISCOVERY (2002)
Discovery of small-molecule inhibitors of bcl-2 through structure-based computer screening
IJ Enyedy et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
Organelle-specific initiation of cell death pathways
KF Ferri et al.
NATURE CELL BIOLOGY (2001)
Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion
M Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
MC Wei et al.
SCIENCE (2001)
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3
SP Tzung et al.
NATURE CELL BIOLOGY (2001)
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bc12 and perturbing the cellular redox state
KD McCullough et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL
A Degterev et al.
NATURE CELL BIOLOGY (2001)
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
SJ Korsmeyer et al.
CELL DEATH AND DIFFERENTIATION (2000)
Cardiolipin provides specificity for targeting of tBid to mitochondria
M Lutter et al.
NATURE CELL BIOLOGY (2000)
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
JL Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Nora, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
E Oda et al.
SCIENCE (2000)
Reduced loading of intracellular Ca2+ stores and downregulation of capacitative Ca2+ influx in Bcl-2-overexpressing cells
P Pinton et al.
JOURNAL OF CELL BIOLOGY (2000)
Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane
R Eskes et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)