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Mariko Moriyama et al.
DEVELOPMENTAL CELL (2008)
The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response
Anna Mandinova et al.
EMBO JOURNAL (2008)
Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis
Soline Estrach et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)
Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling
Ilaria Malanchi et al.
NATURE (2008)
Off the beaten pathway: the complex cross talk between Notch and NF-kappa B
Clodia Osipo et al.
LABORATORY INVESTIGATION (2008)
Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of γ-secretase
Tong Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Overexpressed active Notch1 induces cell growth arrest of HeLa cervical carcinoma cells
L. Wang et al.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2007)
Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung
Yuanbin Chen et al.
CANCER RESEARCH (2007)
Corneal epithelial cell fate is maintained during repair by notch1 signaling via the regulation of vitamin a metabolism
Sophie Vauclair et al.
DEVELOPMENTAL CELL (2007)
Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes
Jonghyeob Lee et al.
DEVELOPMENT (2007)
p53 homologue, p51/p63, maintains the immaturity of keratinocyte stem cells by inhibiting Notch1 activity
R. Okuyama et al.
ONCOGENE (2007)
Regulation of Notch1 gene expression by p53 in epithelial cells
Takashi Yugawa et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Restoration of p53 expression in human cancer cell lines upregulates the expression of Notch1: Implications for cancer cell fate determination after genotoxic stress
Fatouma Alimirah et al.
NEOPLASIA (2007)
Notch1 induces cell cycle arrest and apoptosis in human cervical cancer cells: involvement of nuclear factor kappa B inhibition
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INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2007)
Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKα kinases
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GENES & DEVELOPMENT (2007)
Coexpression of Notch1 and NF-κB signaling pathway components in human cervical cancer progression
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GYNECOLOGIC ONCOLOGY (2007)
Notch signaling is necessary for epithelial growth arrest by TGF-β
Hideki Niimi et al.
JOURNAL OF CELL BIOLOGY (2007)
Cell type and DNA damage specific response of human skin cells to environmental agents
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MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2007)
Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Cancer as an evolutionary and ecological process
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NATURE REVIEWS CANCER (2006)
p63 regulates proliferation and differentiation of developmentally mature keratinocytes
Amy B. Truong et al.
GENES & DEVELOPMENT (2006)
Canonical Notch signaling functions as a commitment switch in the epidermal lineage
Cedric Blanpain et al.
GENES & DEVELOPMENT (2006)
A FoxO-Smad synexpression group in human keratinocytes
Roger R. Gomis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Impaired Notch signaling promotes de novo squamous cell carcinoma formation
Aaron Proweller et al.
CANCER RESEARCH (2006)
Defining the transcriptome of accelerated and replicatively senescent keratinocytes reveals links to differentiation, interferon signaling, and Notch related pathways
RJ Perera et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2006)
Survival signaling by Notch1: Mammalian target of rapamycin (mTOR)-dependent inhibition of p53
Sathish Kumar Mungamuri et al.
CANCER RESEARCH (2006)
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation
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GENES & DEVELOPMENT (2006)
p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation
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DEVELOPMENT (2006)
Cdc42 controls progenitor cell differentiation and β-catenin turnover in skin
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GENES & DEVELOPMENT (2006)
A global map of p53 transcription-factor binding sites in the human genome
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CELL (2006)
Notch1 augments NF-κB activity by facilitating its nuclear retention
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EMBO JOURNAL (2006)
NOTCH signaling as a novel cancer therapeutic target
L. Miele et al.
CURRENT CANCER DRUG TARGETS (2006)
Notch signalling: a simple pathway becomes complex
Sarah J. Bray
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies
PA Zweidler-McKay et al.
BLOOD (2005)
Activation of Notch1 signaling is required for β-catenin-mediated human primary melanoma progression
K Balint et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit the JNK signaling pathway
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
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GENES & DEVELOPMENT (2005)
Suppression of p53 by Notch in lymphomagenesis: Implications for initiation and regression
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CANCER RESEARCH (2005)
Stem cell depletion through epidermal deletion of Rac1
SA Benitah et al.
SCIENCE (2005)
P21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation
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GENES & DEVELOPMENT (2005)
Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways
C Talora et al.
EXPERIMENTAL CELL RESEARCH (2005)
Integration of Notch 1 and Calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control
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DEVELOPMENTAL CELL (2005)
Notch4 inhibits endothelial apoptosis via RBP-Jκ-dependent and -independent pathways
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Integration of TGF-β/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
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EMBO JOURNAL (2004)
p53 regulates thymic Notch1 activation
AM Laws et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2004)
Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells
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EMBO JOURNAL (2004)
The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells
H Sade et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach
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CANCER CELL (2004)
Mastermind critically regulates Notch-mediated lymphoid cell fate decisions
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BLOOD (2004)
Species- and cell type-specific requirements for cellular transformation
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CANCER CELL (2004)
Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis
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DEVELOPMENTAL BIOLOGY (2004)
NF-kappa B RelA poses epidermal proliferation riven by TNFR1 and JNK
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GENES & DEVELOPMENT (2004)
LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis
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GENES & DEVELOPMENT (2004)
WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating DII1 expression in the presomitic mesoderm of mouse embryos
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GENES & DEVELOPMENT (2004)
p63: molecular complexity in development and cancer
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CARCINOGENESIS (2004)
γ-secretase functions through notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis
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DEVELOPMENTAL CELL (2004)
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway
XD Yang et al.
DEVELOPMENTAL BIOLOGY (2004)
p63 and epithelial appendage development
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DIFFERENTIATION (2004)
Cross-talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3
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JOURNAL OF CELL BIOLOGY (2003)
Differential expression of cyclin D1 in the human hair follicle
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AMERICAN JOURNAL OF PATHOLOGY (2003)
ΔNp63α functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes
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ONCOGENE (2003)
Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway
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JOURNAL OF VIROLOGY (2003)
Notch1 functions as a tumor suppressor in mouse skin
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NATURE GENETICS (2003)
HES and HERP families: Multiple effectors of the Notch signaling pathway
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JOURNAL OF CELLULAR PHYSIOLOGY (2003)
Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells
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CURRENT BIOLOGY (2003)
NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia
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NATURE (2003)
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling
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MOLECULAR AND CELLULAR BIOLOGY (2003)
Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation
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GENES & DEVELOPMENT (2002)
Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins
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EMBO REPORTS (2002)
Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-κB and PPARγ
BJ Nickoloff et al.
CELL DEATH AND DIFFERENTIATION (2002)
Cell cycle and death control: long live Forkheads
BMT Burgering et al.
TRENDS IN BIOCHEMICAL SCIENCES (2002)
Notch signaling induces rapid degradation of achaete-scute homolog 1
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MOLECULAR AND CELLULAR BIOLOGY (2002)
Modelling the molecular circuitry of cancer
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NATURE REVIEWS CANCER (2002)
Sp100 interacts with ETS-1 and stimulates its transcriptional activity
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MOLECULAR AND CELLULAR BIOLOGY (2002)
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NATURE GENETICS (2002)
Structure and function of IRF-7
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JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2002)
The promise of retinoids to fight against cancer
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NATURE REVIEWS CANCER (2001)
p300 acts as a transcriptional coactivator for mammalian Notch-1
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MOLECULAR AND CELLULAR BIOLOGY (2001)
The epidemiology of UV induced skin cancer
BK Armstrong et al.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2001)
Loss of presenilin 1 is associated with enhanced β-catenin signaling and skin tumorigenesis
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
A specific isozyme of 2′-5′ oligoadenylate synthetase is a dual function proapoptotic protein of the Bcl-2 family
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
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EMBO JOURNAL (2001)
p63 identifies keratinocyte stem cells
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Notch signaling: From the outside in
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DEVELOPMENTAL BIOLOGY (2000)
MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors
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NATURE GENETICS (2000)
Mastermind is a putative activator for Notch
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CURRENT BIOLOGY (2000)
Stimulation of human epidermal differentiation by Delta-Notch signalling at the boundaries of stem-cell clusters
S Lowell et al.
CURRENT BIOLOGY (2000)
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