期刊
ONCOGENE
卷 27, 期 35, 页码 4854-4859出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2008.124
关键词
p53; proteomics; phosphorylation
The p53 tumor suppressor regulates transcription of target genes. We have previously analysed the p53-dependent proteome and identified novel protein targets. Here we have examined p53-dependent phosphorylation using two-dimensional gel electrophoresis and staining with the fluorescent phosphoprotein dye Pro-Q Diamond. We report that p53 induces phosphorylation of a subset of proteins including Nm23, DJ-1, ANXA1 and PrxII. Our identification of p53-dependent phosphorylation of specific target proteins reveals new aspects of the p53-dependent cellular response and suggests that such posttranslational modi. cations may contribute to p53-mediated tumor suppression.
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