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CELL DEATH AND DIFFERENTIATION (2008)
SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization
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Yap1 phosphorylation by c-AbI is a critical step in selective activation of proapoptotic genes in response to DNA damage
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p73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis
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Knockin mice expressing a Chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence
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The proline-rich domain in p63 is necessary for the transcriptional and apoptosis-inducing activities of TAp63
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ONCOGENE (2008)
Properties of the six isoforms of p63:: p53-like regulation in response to genotoxic stress and cross talk with ΔNp73
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CARCINOGENESIS (2008)
Comparative biophysical characterization of p53 with the pro-apoptotic BAK and the anti-apoptotic BCL-xL
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
TAp73 is a downstream target of p53 in controlling the cellular defense against stress
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP
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Hzf determines cell survival upon genotoxic stress by modulating p53 transactivation
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CELL (2007)
p63 and p73 in human cancer: defining the network
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ONCOGENE (2007)
Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis
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MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis
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MOLECULAR CELL (2007)
DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage
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MOLECULAR CELL (2007)
Monoubiquitylation promotes mitochondrial p53 translocation
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EMBO JOURNAL (2007)
FBXO11 promotes the neddylation of p53 and inhibits its transcriptional activity
Wassim M. Abida et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
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Peter E. Shaw
EMBO REPORTS (2007)
The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73
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CELL DEATH AND DIFFERENTIATION (2007)
How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
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CELL DEATH AND DIFFERENTIATION (2007)
Modeling the therapeutic efficacy of p53 restoration in tumors
Carla P. Martins et al.
CELL (2006)
Acetylation of the p53 DNA-binding domain regulates apoptosis induction
Stephen M. Sykes et al.
MOLECULAR CELL (2006)
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
Yi Tang et al.
MOLECULAR CELL (2006)
Regulating the p53 pathway:: in vitro hypotheses, in vivo veritas
Franck Toledo et al.
NATURE REVIEWS CANCER (2006)
One, two, three -: p53, p63, p73 and chemosensitivity
Martina Mueller et al.
DRUG RESISTANCE UPDATES (2006)
Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence
Lijin Feng et al.
CELL CYCLE (2006)
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression
Vishwanie S. Budhram-Mahadeo et al.
NUCLEIC ACIDS RESEARCH (2006)
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation
Laurent Le Cam et al.
CELL (2006)
Prognostic value of increase in transcript levels of Tp73 DEx2-3 isoforms in low-grade glioma patients
M. Wager et al.
BRITISH JOURNAL OF CANCER (2006)
Mitochondrially targeted wild-type p53 suppresses growth of mutant p53 lymphomas in vivo
G. Palacios et al.
ONCOGENE (2006)
Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma
Maurice Phillip DeYoung et al.
CANCER RESEARCH (2006)
p53 family members in myogenic differentiation and rhabdomyosarcoma development
Hakan Cam et al.
CANCER CELL (2006)
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation
Evguenia Strom et al.
NATURE CHEMICAL BIOLOGY (2006)
Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage
Connie Chao et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate
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JOURNAL OF CELL BIOLOGY (2006)
WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization
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JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
ΔTAp73 upregulation correlates with poor prognosis in human tumors:: Putative in vivo network involving p73 isoforms, p53, and E2F-1
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JOURNAL OF CLINICAL ONCOLOGY (2006)
p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis
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CANCER CELL (2006)
p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress
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CELL DEATH AND DIFFERENTIATION (2006)
TAp73/ΔNp73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma
M Müller et al.
CELL DEATH AND DIFFERENTIATION (2005)
Viral and cellular oncogenes induce rapid mitochondrial translocation of p53 in primary epithelial and endothelial cells early in apoptosis
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FEBS LETTERS (2005)
Mitochondrially targeted p53 has tumor suppressor activities in vivo
F Talos et al.
CANCER RESEARCH (2005)
p53 isoforms can regulate p53 transcriptional activity
JC Bourdon et al.
GENES & DEVELOPMENT (2005)
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
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SCIENCE (2005)
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
WM Keyes et al.
GENES & DEVELOPMENT (2005)
HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage
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ONCOGENE (2005)
Ubiquitin and ubiquitin-like proteins as multifunctional signals
RL Welchman et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
TAp63α induces apoptosis by activating signaling via death receptors and mitochondria
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EMBO JOURNAL (2005)
The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA damage
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MOLECULAR CELL (2005)
Tumor predisposition in mice mutant for p63 and p73:: Evidence for broader tumor suppressor functions for the p53 family
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CANCER CELL (2005)
Brn-3a transcription factor blocks p53-mediated activation of proapoptotic target genes Noxa and Bax in vitro and in vivo to determine cell fate
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Perp is a p63-regulated gene essential for epithelial integrity
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CELL (2005)
BH3 domains of BH3-only proteins differentially regulate bax-mediated mitochondrial membrane permeabilization both directly and indirectly
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Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
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CANCER CELL (2005)
The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality
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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
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NATURE CELL BIOLOGY (2004)
Transdominant ΔTAp73 isoforms are frequently up-regulated in ovarian cancer.: Evidence for their role as epigenetic p53 inhibitors in vivo
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CANCER RESEARCH (2004)
p73 induces apoptosis via PUMA transactivation and Bax mitochondrial translocation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
JE Chipuk et al.
SCIENCE (2004)
Defining the p53 DNA-binding domain BcL-XL-binding interface using NMR
AM Petros et al.
FEBS LETTERS (2004)
ASPP1 and ASPP2: Common activators of p53 family members
D Bergamaschi et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
In vivo mitochondrial p53 transloclation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation
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MOLECULAR AND CELLULAR BIOLOGY (2004)
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
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CELL (2004)
Dominant negative p63 isoform expression in head and neck squamous cell carcinoma
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LARYNGOSCOPE (2004)
P63 and p73 are not required for the development and p53-dependent apoptosis of T cells
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CANCER CELL (2004)
Pin1 links the activities of c-Abl and p300 in regulating p73 function
F Mantovani et al.
MOLECULAR CELL (2004)
Post-translational modification of p53 in tumorigenesis
AM Bode et al.
NATURE REVIEWS CANCER (2004)
Mono-versus polyubiquitination: Differential control of p53 fate by Mdm2
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SCIENCE (2003)
Control of apoptosis by p53
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ONCOGENE (2003)
p53- and drug-induced apoptotic responses mediated by BH3-only proteins Puma and Noxa
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SCIENCE (2003)
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
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CANCER CELL (2003)
Differential regulation of E2F1 apoptotic target genes in response to DNA damage
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NATURE CELL BIOLOGY (2003)
The ΔNp63α phosphoprotein binds the p21 and 14-3-3σ promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations
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MOLECULAR AND CELLULAR BIOLOGY (2003)
p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
D Bergamaschi et al.
CANCER CELL (2003)
p53 has a direct apoptogenic role at the mitochondria
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MOLECULAR CELL (2003)
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
P Dumont et al.
NATURE GENETICS (2003)
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
D Bergamaschi et al.
NATURE GENETICS (2003)
Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
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MOLECULAR CELL (2003)
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G Melino et al.
TRENDS IN BIOCHEMICAL SCIENCES (2003)
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response
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NATURE (2002)
Loss of p63 expression is associated with tumor progression in bladder cancer
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AMERICAN JOURNAL OF PATHOLOGY (2002)
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CANCER CELL (2002)
The BCL2 family: Regulators of the cellular life-or-death switch
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NATURE REVIEWS CANCER (2002)
Differential regulation of transcription and induction of programmed cell death by human p53-family members p63 and p73
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FEBS LETTERS (2002)
Live or let die: The cell's response to p53
KH Vousden et al.
NATURE REVIEWS CANCER (2002)
p53 induces the expression of its antagonist p73ΔN, establishing an autoregulatory feedback loop
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ONCOGENE (2002)
p53 gene family p51 (p63)-encoded, secondary transactivator p51 B(TAp63α) occurs without forming an immunoprecipitable complex with MDM2, but responds to genotoxic stress by accumulation
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EXPERIMENTAL CELL RESEARCH (2002)
Physical interaction with human tumor-derived p53 mutants inhibits p63 activities
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Expression of p53 and its homologues in primary and recurrent squamous cell carcinomas of the head and neck
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INTERNATIONAL JOURNAL OF CANCER (2002)
Transactivation-deficient △TA-p73 inhibits p53 by direct competition for DNA binding -: Implications for tumorigenesis
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
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NATURE (2002)
Regulation of p73 by c-Abl through the p38 MAP kinase pathway
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ONCOGENE (2002)
The IARC TP53 database: New Online mutation analysis and recommendations to users
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HUMAN MUTATION (2002)
DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes
A Costanzo et al.
MOLECULAR CELL (2002)
Multiple roles of the tumor suppressor p53
J Bargonetti et al.
CURRENT OPINION IN ONCOLOGY (2002)
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases
NA Barlev et al.
MOLECULAR CELL (2001)
Human ΔNp73 regulates a dominant negative feedback loop for TAp73 and p53
TJ Grob et al.
CELL DEATH AND DIFFERENTIATION (2001)
ASPP proteins specifically stimulate the apoptotic function of p53
Y Samuels-Lev et al.
MOLECULAR CELL (2001)
p63α and ΔNp63α can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes
M Dohn et al.
ONCOGENE (2001)
Physical interaction with Yes-associated protein enhances p73 transcriptional activity
S Strano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
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Oncogenes induce and activate endogenous p73 protein
A Zaika et al.
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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain
C Gaiddon et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
p73 is transcriptionally regulated by DNA damage, p53, and p73
XB Chen et al.
ONCOGENE (2001)
Hypoxia death stimulus induces translocation of p53 protein to mitochondria - Detection by immunofluorescence on whole cells
C Sansome et al.
FEBS LETTERS (2001)
Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool
JL Luo et al.
ONCOGENE (2001)
Essential role for caspase-8 in transcription-independent apoptosis triggered by p53
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Role for the p53 homologue p73 in E2F-1-induced apoptosis
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NATURE (2000)
p53AlP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
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CELL (2000)
p51A (TAp63γ), a p53 homolog, accumulates in response to DNA damage for cell regulation
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ONCOGENE (2000)
Death signal-induced localization of p53 protein to mitochondria - A potential role in apoptotic signaling
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
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NATURE GENETICS (2000)
p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
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NATURE (2000)
The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis
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MOLECULAR AND CELLULAR BIOLOGY (2000)
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