期刊
ONCOGENE
卷 27, 期 2, 页码 225-233出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1210907
关键词
ovarian cancer; Toll-like receptors; MyD88; inflammation; tissue repair; chemoresistance
Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore, it would not be surprising that factors that function in the tissue repair process, such as cytokines, chemokines, growth factors and Toll-like receptor (TLR) ligands, as well as growth signals for compensatory proliferation, would also be key factors in regulating and enhancing cancer progression. The TLR pathways, which play a critical role in tissue repair, are also key regulators in cancer progression as well as chemoresistance. TLRs serve as cell surface sensors that can initiate pathways leading to proliferation and chemoresistance; as well as mediators that are able to regulate the infiltrating immune cells to provide further support for cancer progression.
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