相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Bcl-2 family members - Dual regulators of apoptosis and autophagy
Beth Levine et al.
AUTOPHAGY (2008)
Autophagy in the pathogenesis of disease
Beth Levine et al.
CELL (2008)
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
Ralph J. DeBerardinis et al.
CELL METABOLISM (2008)
cAMP-dependent protein kinase regulates the mitochondrial import of the nuclear encoded NDUFS4 subunit of complex I
Domenico De Rasmo et al.
CELLULAR SIGNALLING (2008)
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Gilad Twig et al.
EMBO JOURNAL (2008)
Transplacental exposure to the vacuolar-ATPase inhibitor bafilomycin disrupts survival signaling in β cells and delays neonatal remodeling of the endocrine pancreas
Kalindi D. Hettiarachchi et al.
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY (2008)
Phosphorylation of bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1
Hongbin Deng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Bcl-xL inhibitor ABT-737 reveals a dual role for Bcl-xL in synaptic transmission
John A. Hickman et al.
JOURNAL OF NEUROPHYSIOLOGY (2008)
BAX activation is initiated at a novel interaction site
Evripidis Gavathiotis et al.
NATURE (2008)
Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint
Edward Owusu-Ansah et al.
NATURE GENETICS (2008)
Dual role of proapoptotic BAD in insulin secretion and beta cell survival
Nika N. Danial et al.
NATURE MEDICINE (2008)
The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons
Takahiro Miyawaki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Bcl-XL induces Drp1-dependent synapse formation in cultured hippocampal neurons
Hongmei Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines
Jee Young Sung et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
Jerry E. Chipuk et al.
TRENDS IN CELL BIOLOGY (2008)
Bcl-XL inhibits membrane permeabilization by competing with Bax
Lieven P. Billen et al.
PLOS BIOLOGY (2008)
A role for F-Actin in hexokinase-mediated glucose signaling1[C][W][OA]
Rajagopal Balasubramanian et al.
PLANT PHYSIOLOGY (2007)
S6K1-mediated disassembly of mitochondrial URI/PP1γ complexes activates a negative feedback program that counters S6K1 survival signaling
Nabil Djouder et al.
MOLECULAR CELL (2007)
β-cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels
Jakob D. Wikstrom et al.
DIABETES (2007)
Pro-apoptotic PUMA and anti-apoptotic Phospho-BAD are highly expressed in colorectal carcinomas
Mi R. Kim et al.
DIGESTIVE DISEASES AND SCIENCES (2007)
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
D. Grahame Hardie
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Distinct in vivo roles of caspase-8 in β-cells in physiological and diabetes models
Nicole Liadis et al.
DIABETES (2007)
BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents
Jing Deng et al.
CANCER CELL (2007)
Modulation of prostate cancer genetic risk by ornega-3 and ornega-6 fatty acids
Isabelle M. Berquin et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
Vassiliki Karantza-Wadsworth et al.
GENES & DEVELOPMENT (2007)
Molecular coordination of hepatic glucose metabolism by the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase:glucokinase complex
W. Ed Smith et al.
MOLECULAR ENDOCRINOLOGY (2007)
Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1
M. Chiara Maiuri et al.
EMBO JOURNAL (2007)
Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation
Konduru S. R. Sastry et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Embedded together: The life and death consequences of interaction of the Bcl-2 family with membranes
Brian Leber et al.
APOPTOSIS (2007)
Crystal structure of the Bcl-XL-beclin 1 peptide complex -: Beclin 1 is a novel BH3-only protein
Adam Oberstein et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
A-kinase anchoring proteins take shape
Darren L. Beene et al.
CURRENT OPINION IN CELL BIOLOGY (2007)
The energy sensing LKB1-AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
Jiyong Liang et al.
NATURE CELL BIOLOGY (2007)
A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory
Scott H. Soderling et al.
JOURNAL OF NEUROSCIENCE (2007)
Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance
Yasuo Terauchi et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells
P. Obexer et al.
CELL DEATH AND DIFFERENTIATION (2007)
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
Hyungjin Kim et al.
NATURE CELL BIOLOGY (2006)
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic (vol 103, pg 14907, 2006)
Junya Kuroda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
A stapled BID BH3 helix directly binds and activates BAX
Loren D. Walensky et al.
MOLECULAR CELL (2006)
Tuberin activates the proapoptotic molecule BAD
A. Freilinger et al.
ONCOGENE (2006)
Role of Bax and Bak in mitochondrial morphogenesis
Mariusz Karbowski et al.
NATURE (2006)
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
Junya Kuroda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Epidermal growth factor protects prostate cancer cells from apoptosis by inducing BAD phosphorylation via redundant signaling pathways
Konduru S. R. Sastry et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
BCL2 family in DNA damage and cell cycle control
S. Zinkel et al.
CELL DEATH AND DIFFERENTIATION (2006)
Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt
R. B. Robey et al.
ONCOGENE (2006)
Bcl-2 and Ca2+ homeostasis in the endoplasmic reticulum
P. Pinton et al.
CELL DEATH AND DIFFERENTIATION (2006)
BH3-only proteins in cell death initiation, malignant disease and anticancer therapy
V. Labi et al.
CELL DEATH AND DIFFERENTIATION (2006)
Mitochondrial factors with dual roles in death and survival
W. -C Cheng et al.
ONCOGENE (2006)
Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia
Jayne M. Ness et al.
BRAIN RESEARCH (2006)
Reversible membrane interaction of BAD requires two C-terminal lipid binding domains in conjunction with 14-3-3 protein binding
Mirko Hekman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Glucokinase regulatory protein is associated with mitochondria in hepatocytes
C Arden et al.
FEBS LETTERS (2006)
Glycolytic enzyme interactions with yeast and skeletal muscle F-actin
VF Waingeh et al.
BIOPHYSICAL JOURNAL (2006)
Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL
A Macdonald et al.
BMC CELL BIOLOGY (2006)
Minireview: Implication of mitochondria in insulin secretion and action
Andreas Wiederkehr et al.
ENDOCRINOLOGY (2006)
Mitochondrial AKAP121 links cAMP and src signaling to oxidative metabolism
A Livigni et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Cerebral preconditioning and ischaemic tolerance
Jeffrey M. Gidday
NATURE REVIEWS NEUROSCIENCE (2006)
Mitochondrial regulation of cell cycle progression during development as by the tenured mutation revealed in Drosophila
S Mandal et al.
DEVELOPMENTAL CELL (2005)
The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells
QB She et al.
CANCER CELL (2005)
Autophagy in cell death: an innocent convict?
B Levine et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
The survival kinases Akt and Pim as potential pharmacological targets
R Amaravadi et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
S Pattingre et al.
CELL (2005)
Exposure to chronic high glucose induces β-cell apoptosis through decreased interaction of glucokinase with mitochondria -: Downregulation of glucokinase in pancreatic β-cells
WH Kim et al.
DIABETES (2005)
Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells
R Götz et al.
NATURE NEUROSCIENCE (2005)
Proapoptotic BID is an ATM effector in the DNA-damage response
I Kamer et al.
CELL (2005)
A role for proapoptotic BID in the DNA-damage response
SS Zinkel et al.
CELL (2005)
Mechanisms of compensatory β-cell growth in insulin-resistant rats -: Roles of Akt kinase
TL Jetton et al.
DIABETES (2005)
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T Oltersdorf et al.
NATURE (2005)
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
RG Jones et al.
MOLECULAR CELL (2005)
BH3 domains of BH3-only proteins differentially regulate bax-mediated mitochondrial membrane permeabilization both directly and indirectly
T Kuwana et al.
MOLECULAR CELL (2005)
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
L Chen et al.
MOLECULAR CELL (2005)
Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury
AK Bose et al.
DIABETES (2005)
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
JJ Lum et al.
CELL (2005)
Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice
H Sone et al.
DIABETOLOGIA (2005)
High frequency of mutations of the PIK3CA gene in human cancers
Y Samuels et al.
SCIENCE (2004)
Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines
L Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
PKA: a portrait of protein kinase dynamics
SS Taylor et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2004)
Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP)
HC Dan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
CF Yu et al.
MOLECULAR CELL (2004)
Cell death: Critical control points
NN Danial et al.
CELL (2004)
Enhanced redundancy in Akt and mitogen-activated protein kinase-induced survival of malignant versus normal prostate epithelial cells
AR Uzgare et al.
CANCER RESEARCH (2004)
Inactivating mutations of proapoptotic Bad gene in human colon cancers
JW Lee et al.
CARCINOGENESIS (2004)
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
Z Li et al.
CELL (2004)
Positive correlation between overexpression of phospho-BAD with phosphorylated Akt at serine 473 but not threonine 308 in colorectal carcinoma
TO Khor et al.
CANCER LETTERS (2004)
Interleukin-7 inactivates the pro-apoptotic protein bad promoting T cell survival
WQ Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Apoptosis, autophagy, and more
RA Lockshin et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
Bcl-xL sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers
SY Jeong et al.
EMBO JOURNAL (2004)
BAD is a pro-survival factor prior to activation of its pro-apoptotic function
SY Seo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
B Yan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry
YM Janumyan et al.
EMBO JOURNAL (2003)
Enzymes of glycolysis are functionally associated with the mitochondrion in Arabidopsis cells
P Giegé et al.
PLANT CELL (2003)
Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis
CW Chiang et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
NN Danial et al.
NATURE (2003)
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons
J Gilley et al.
JOURNAL OF CELL BIOLOGY (2003)
Bad-deficient mice develop diffuse large B cell lymphoma
AM Ranger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
CJ Fox et al.
GENES & DEVELOPMENT (2003)
p21-activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD
S Cotteret et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Regulation of cell death: The calcium-apoptosis link
S Orrenius et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent pathways cooperate to maintain lung cancer cell survival
HY Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function
JE Wilson
JOURNAL OF EXPERIMENTAL BIOLOGY (2003)
Role of the Arabidopsis glucose sensor HXK1 in nutrient, light, and hormonal signaling
B Moore et al.
SCIENCE (2003)
Essential role of A-kinase anchor protein 121 for cAMP signaling to mitochondria
A Affaitati et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
SR Datta et al.
DEVELOPMENTAL CELL (2002)
Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic β-cell death
WL Liu et al.
ENDOCRINOLOGY (2002)
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
A Letai et al.
CANCER CELL (2002)
Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor
AP Gilmore et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets -: Evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
R Lupi et al.
DIABETES (2002)
Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery
Y Konishi et al.
MOLECULAR CELL (2002)
Transforming growth factor beta 1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cells
BC Kim et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis
JG Pastorino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice
N Noshita et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2001)
Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the Ras guanine nucleotide exchange factor CDC25Mm/Ras-GRF1
N Gnesutta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, in a human hepatocellular carcinoma cell line
K Imamura et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Growth factors can influence cell growth and survival through effects on glucose metabolism
MG Vander Heiden et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD
H Harada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
BAD/BCL-xL heterodimerization leads to bypass of G0/G1 arrest
A Chattopadhyay et al.
ONCOGENE (2001)
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
K Gottlob et al.
GENES & DEVELOPMENT (2001)
High glucose causes apoptosis in cultured human pancreatic Islets of Langerhans - A potential role for regulation of specific Bcl family genes toward an apoptotic cell death program
M Federici et al.
DIABETES (2001)
Caspase cleavage enhances the apoptosis-inducing effects of BAD
F Condorelli et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
MC Wei et al.
SCIENCE (2001)
Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus
S Yano et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2001)
Apoptosis suppression by Raf-1 and MEK1 requires MEK-and phosphatidylinositol 3-kinase-dependent signals
A von Gise et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin-3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation
CW Chiang et al.
BLOOD (2001)
Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons
S Wiese et al.
NATURE NEUROSCIENCE (2001)
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies
AM Petros et al.
PROTEIN SCIENCE (2000)
The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues
T Lindsten et al.
MOLECULAR CELL (2000)
Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival
K Virdee et al.
CURRENT BIOLOGY (2000)
BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival
Y Tan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155
XM Zhou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Linear correlation between β-cell mass and body weight throughout the lifespan in Lewis rats -: Role of β-cell hyperplasia and hypertrophy
E Montanya et al.
DIABETES (2000)
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155
JM Lizcano et al.
BIOCHEMICAL JOURNAL (2000)
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
SR Datta et al.
MOLECULAR CELL (2000)
Protein phosphatase 1α is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis
V Ayllón et al.
EMBO JOURNAL (2000)
Increased and persistent circulating insulin-like growth factor II in neonatal transgenic mice suppresses developmental apoptosis in the pancreatic islets
DJ Hill et al.
ENDOCRINOLOGY (2000)
p21-activated kinase 1 phosphorylates the death agonist Bad and protects cells from apoptosis
A Schurmann et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold
RS Westphal et al.
EMBO JOURNAL (2000)