4.8 Review

BAD: undertaker by night, candyman by day

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FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells

P. Obexer et al.

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Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

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Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic (vol 103, pg 14907, 2006)

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A stapled BID BH3 helix directly binds and activates BAX

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BH3-only proteins in cell death initiation, malignant disease and anticancer therapy

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Mitochondrial factors with dual roles in death and survival

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ONCOGENE (2006)

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Reversible membrane interaction of BAD requires two C-terminal lipid binding domains in conjunction with 14-3-3 protein binding

Mirko Hekman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Glucokinase regulatory protein is associated with mitochondria in hepatocytes

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FEBS LETTERS (2006)

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Glycolytic enzyme interactions with yeast and skeletal muscle F-actin

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S Pattingre et al.

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Proapoptotic BID is an ATM effector in the DNA-damage response

I Kamer et al.

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A role for proapoptotic BID in the DNA-damage response

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

T Oltersdorf et al.

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High frequency of mutations of the PIK3CA gene in human cancers

Y Samuels et al.

SCIENCE (2004)

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L Wu et al.

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HC Dan et al.

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JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD

CF Yu et al.

MOLECULAR CELL (2004)

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Cell death: Critical control points

NN Danial et al.

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Interleukin-7 inactivates the pro-apoptotic protein bad promoting T cell survival

WQ Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Biochemistry & Molecular Biology

Apoptosis, autophagy, and more

RA Lockshin et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Bcl-xL sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers

SY Jeong et al.

EMBO JOURNAL (2004)

Article Biochemistry & Molecular Biology

BAD is a pro-survival factor prior to activation of its pro-apoptotic function

SY Seo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

B Yan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry

YM Janumyan et al.

EMBO JOURNAL (2003)

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Enzymes of glycolysis are functionally associated with the mitochondrion in Arabidopsis cells

P Giegé et al.

PLANT CELL (2003)

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Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis

CW Chiang et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)

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Bad-deficient mice develop diffuse large B cell lymphoma

AM Ranger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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p21-activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD

S Cotteret et al.

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Regulation of cell death: The calcium-apoptosis link

S Orrenius et al.

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Essential role of A-kinase anchor protein 121 for cAMP signaling to mitochondria

A Affaitati et al.

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Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery

Y Konishi et al.

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EUKARYOTIC CELL (2002)

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Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis

JG Pastorino et al.

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Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice

N Noshita et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2001)

Article Biochemistry & Molecular Biology

Growth factors can influence cell growth and survival through effects on glucose metabolism

MG Vander Heiden et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Multidisciplinary Sciences

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

H Harada et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Biochemistry & Molecular Biology

BAD/BCL-xL heterodimerization leads to bypass of G0/G1 arrest

A Chattopadhyay et al.

ONCOGENE (2001)

Article Biochemistry & Molecular Biology

Caspase cleavage enhances the apoptosis-inducing effects of BAD

F Condorelli et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

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Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus

S Yano et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2001)

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Apoptosis suppression by Raf-1 and MEK1 requires MEK-and phosphatidylinositol 3-kinase-dependent signals

A von Gise et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

AM Petros et al.

PROTEIN SCIENCE (2000)

Article Biochemistry & Molecular Biology

BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival

Y Tan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Biochemistry & Molecular Biology

Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155

XM Zhou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

Article Biochemistry & Molecular Biology

Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155

JM Lizcano et al.

BIOCHEMICAL JOURNAL (2000)

Article Biochemistry & Molecular Biology

14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation

SR Datta et al.

MOLECULAR CELL (2000)

Article Biochemistry & Molecular Biology

p21-activated kinase 1 phosphorylates the death agonist Bad and protects cells from apoptosis

A Schurmann et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)

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Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold

RS Westphal et al.

EMBO JOURNAL (2000)