期刊
OCULAR SURFACE
卷 11, 期 1, 页码 47-53出版社
ETHIS COMMUNICATINS, INC
DOI: 10.1016/j.jtos.2012.09.005
关键词
aging; length of meibomian gland duct; meibomian gland dropout; meibomian gland morphology; meibomian glands; noncontact infrared meibography; ocular surface; percent area of meibomian gland acini
资金
- Japanese Ministry of Education, Culture, Sports, Science and Technology (Tokyo, Japan) [22791690]
- Grants-in-Aid for Scientific Research [22791690] Funding Source: KAKEN
Meibography is used to study morphological changes in the meibomian glands (MGs), and semi-quantitative analysis has been used for MG assessment. We conducted a detailed morphometric assessment of MGs using noncontact infrared meibography (NIM) and investigated the relationship between MG morphology and the ocular surface and MG morphology associated with aging and sex in 37 subjects. The MGs in the upper and lower eyelids showed significant correlations in their morphology, with the former having longer ducts than the latter. The mean length of the MG ducts, percent area of MG acini, and number of gland dropouts were significantly correlated with age. The mean length of the MG ducts in the upper and lower eyelids showed negative correlations with the meibum (P=.043) and fluorescein staining score (P=.008), respectively. The percent area of MG acini in the upper eyelid showed a positive correlation with tear film breakup time (P=.012) and negative correlations with tear film lipid layer interferometry and meibum (P=.005 and .002, respectively). The mean length of the male's MG ducts in the lower eyelid was significantly longer than that of the females (P=.03). These results indicate that morphometric analysis using NIM may be useful for assessing ocular surface conditions.
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