期刊
OCULAR SURFACE
卷 7, 期 1, 页码 11-27出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1542-0124(12)70289-6
关键词
animal models; autoimmune disease; genomics; keratoconjunctivitis sicca; proteomics; Sjogren syndrome; stomatitis sicca
资金
- PHS [DE-014344, T 32 DL07200]
- National Institute of Health
- University of Florida's Center for Orphan Autoimmune Diseases
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [T32DE007200, R01DE014344] Funding Source: NIH RePORTER
Sjogren syndrome (SS) Is one of the most common autoimmune diseases. Early clinical manifestations of SS are primarily decreased tear and saliva secretion, leading to dry eye and dry mouth syndromes, but In Its later stages, It can become systemic, even resulting In B call lymphomas. The use of new animal models, coupled with new technologies, Is providing exciting Insights into the pathogenesis, genetic predisposition, and, possibly, early diagnosis of SS. This article reviews newly described features of SS Identified In experimental animal models and their relationship to human disease. New technologies, such as genomics and proteomics, may permit Identification of potential candidate genes and biomarkers for disease diagnosis. Current studies using appropriate animal models In parallel with studies of human subjects are rapidly establishing a foundation for new Intervention strategies that go beyond merely treating symptoms.
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