期刊
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
卷 69, 期 12, 页码 883-889出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/oemed-2012-100826
关键词
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资金
- CIC-Inserm of Necker
- Grenoble
- Marseille
- French Agency of health safety, environment and work [AFSSET-EST-09-15]
- Hospital programme of clinical research (PHRC)-Paris (ANR-SEST)
- National Research Agency-Health environment, health-work programme
- Merck Sharp Dohme (MSD)
- Isere committee against respiratory diseases (COMARES)
- French Ministry of foreign and European affairs/Netherland organisation for scientific research (NWO) Van Gogh programme for French Dutch cooperation
- University Paris [Sud 11 - ED420]
Objective Cleaning products may cause work-related asthma, but information regarding the specific exposures involved is scarce. We aimed to determine the associations between asthma and occupational exposure to cleaning agents in hospital workers. Methods Analyses were conducted in 179 (136 women) hospital workers and a reference population of 545 subjects (18-79 years) from the French case-control and familial Epidemiological study on the Genetics and Environment of Asthma (2003-2007). Exposures to cleaning agents were estimated using three methods: self-report, expert assessment and an asthma-specific job-exposure matrix (JEM). Associations between cleaning products and current asthma were evaluated by logistic regressions, stratified by sex and adjusted for age and smoking status. Results According to expert assessment, 55% of male and 81% of female hospital workers were exposed to cleaning/disinfecting tasks weekly (p<0.001). No association was observed between cleaning/disinfecting tasks and current asthma in men or in women whatever the assessment method used. In women, exposure to decalcifiers (expert assessment) was associated with current asthma (OR (95% CI):2.38 (1.06 to 5.33)). In hospital workers classified as exposed according to both the expert assessment and the JEM, additional associations were observed for exposure to ammonia (3.05 (1.19 to 7.82)) and to sprays with moderate/high intensity (2.87 (1.02 to 8.11)). Conclusions Female hospital workers are often exposed to numerous cleaning products, some of which were markedly associated with current asthma. Low numbers prevented a meaningful analysis in men. Objective and more accurate estimates of occupational exposure to cleaning products are needed to better understand the adverse effects of cleaning products.
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