Sickle Cell Disease in Pregnancy

The term sickle cell disease (SSD) encompasses several different sickle hemoglobinopathies. The ability to predict the clinical course of SSD during pregnancy is difficult. This article examines pregnancy-associated complications in SSD and the management of sickle cell disorders in pregnant women. Outcomes have improved for pregnant women with SSD and nowadays the majority can achieve a successful live birth. However, pregnancy is still associated with an increased incidence of morbidity and mortality. Optimal management during pregnancy should be directed at preventing pain crises, chronic organ damage, optimization of fetal health and minimizing early maternal mortality using a multidisciplinary team approach and prompt, effective and safe relief of acute pain episodes.